A long-sought-after reactive monophosphine-ligated palladium(0) intermediate, Pd0L (L = phosphine ligand), was detected for the first time from the activation of the Buchwald precatalyst with base. The detection was enabled using desorption electrospray ionization mass spectrometry (DESI-MS) in combination with online reaction monitoring. The subsequent oxidative addition of Pd0L with aryl halide and C-N coupling with amine via reductive elimination was also probed using DESI-MS.
All Science Journal Classification (ASJC) codes
- Colloid and Surface Chemistry