Capture of Reactive Monophosphine-Ligated Palladium(0) Intermediates by Mass Spectrometry

Qiuling Zheng, Yong Liu, Qinghao Chen, Meihong Hu, Roy Helmy, Edward C. Sherer, Christopher J. Welch, Hao Chen

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

A long-sought-after reactive monophosphine-ligated palladium(0) intermediate, Pd0L (L = phosphine ligand), was detected for the first time from the activation of the Buchwald precatalyst with base. The detection was enabled using desorption electrospray ionization mass spectrometry (DESI-MS) in combination with online reaction monitoring. The subsequent oxidative addition of Pd0L with aryl halide and C-N coupling with amine via reductive elimination was also probed using DESI-MS.

Original languageEnglish (US)
Pages (from-to)14035-14038
Number of pages4
JournalJournal of the American Chemical Society
Volume137
Issue number44
DOIs
StatePublished - Nov 11 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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