Cardiac Tissue Engineering

Eun Jung Lee, Pamela Hitscherich

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

The development of functional cardiac tissue in vitro for replacing damaged heart tissues and eventually improving heart function is considered as a promising approach. This chapter discusses ongoing research efforts toward ultimately developing functional cardiac replacement tissue. Current challenges include selection of a suitable and abundant cell source for constructing physiologic tissues, mimicking native anisotropic structure and function, providing appropriate biophysical stimulations, and developing vascularized tissues for better survival and integration in vivo. In addition, various in vitro models, which can be used for investigating cardiac development and pathologies as well as for high-throughput drug screening applications, are discussed. Various cell types considered for cardiac regeneration, including mesenchymal stem cells (MSCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs). Various strategies have been employed in developing 3D cardiac tissue constructs using numerous types of biomaterials including hydrogels, fibrous scaffolds, and cell-mediated or scaffold-free biomaterials.

Original languageEnglish (US)
Title of host publicationTissue Engineering for Artificial Organs
Subtitle of host publicationRegenerative Medicine, Smart Diagnostics and Personalized Medicine
PublisherWiley-VCH Verlag
Pages413-443
Number of pages31
Volume2-2
ISBN (Electronic)9783527689934
ISBN (Print)9783527338634
DOIs
StatePublished - Jan 1 2016

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Keywords

  • Biomaterials
  • Cardiac regeneration
  • Cardiac tissue architecture
  • Cardiac tissue engineering
  • Cell source considerations
  • Damaged heart tissues
  • Embryonic stem cells
  • In vitro models
  • Induced pluripotent stem cells
  • Mesenchymal stem cells

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