Characterization of nonlinear elasticity for biological tissue using quantitative optical coherence elastography

Yi Qiu, Farzana R. Zaki, Namas Chandra, Shawn Chester, Xuan Liu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We developed a quantitative optical coherence elastography (qOCE) system for nonlinear mechanical characterization of biological tissues. The fiber-optic probe of the qOCE system had an integrated Fabry-Perot force sensor. To perform mechanical characterization, the tissue was compressed uniaxially by the fiber-optic probe of the qOCE system. Using the optical coherence tomography (OCT) signal detected by a spectral domain OCT engine, we were able to simultaneously quantify the force exerted to the tissue and the displacement of tissue. The quantification of the force was critical for accurate assessment of the elastic behavior of tissue, because most biological tissues have nonlinear elastic behavior. We performed qOCE characterization on tissue mimicking phantoms and biological tissues. Our results demonstrated the capability of the qOCE system for linear and nonlinear assessment of tissue elasticity.

Original languageEnglish (US)
Title of host publicationOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI
EditorsValery V. Tuchin, Joseph A. Izatt, James G. Fujimoto, Valery V. Tuchin
PublisherSPIE
ISBN (Electronic)9781510605473
DOIs
StatePublished - Jan 1 2017
EventOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI - San Francisco, United States
Duration: Jan 29 2017Feb 1 2017

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10053
ISSN (Print)1605-7422

Other

OtherOptical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI
CountryUnited States
CitySan Francisco
Period1/29/172/1/17

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Characterization of nonlinear elasticity for biological tissue using quantitative optical coherence elastography'. Together they form a unique fingerprint.

Cite this