Characterizing variation in the functional connectome: Promise and pitfalls

Clare Kelly, Bharat B. Biswal, R. Cameron Craddock, F. Xavier Castellanos, Michael P. Milham

Research output: Contribution to journalReview articlepeer-review

207 Scopus citations


The functional MRI (fMRI) community has zealously embraced resting state or intrinsic functional connectivity approaches to mapping brain organization. Having demonstrated their utility for charting the large-scale functional architecture of the brain, the field is now leveraging task-independent methods for the investigation of phenotypic variation and the identification of biomarkers for clinical conditions. Enthusiasm aside, questions regarding the significance and validity of intrinsic brain phenomena remain. Here, we discuss these challenges and outline current developments that, in moving the field toward discovery science, permit a shift from cartography toward a mechanistic understanding of the neural bases of variation in cognition, emotion and behavior.

Original languageEnglish (US)
Pages (from-to)181-188
Number of pages8
JournalTrends in Cognitive Sciences
Issue number3
StatePublished - Mar 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience


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