TY - JOUR
T1 - Characterizing variation in the functional connectome
T2 - Promise and pitfalls
AU - Kelly, Clare
AU - Biswal, Bharat B.
AU - Craddock, R. Cameron
AU - Castellanos, F. Xavier
AU - Milham, Michael P.
N1 - Funding Information:
This work was supported by grants from the National Institute of Mental Health (R01MH083246 and R01MH081218 to F.X.C. and M.P.M.; BRAINS R01MH094639 to M.P.M.; R01AG032088 to B.B.B.), the National Institute of Child Health and Human Development (R01HD065282 to F.X.C.), the Leon Levy Foundation (C.K. and M.P.M.), the Brain and Behavior Research Foundation (R.C.C.), as well as Autism Speaks and the Stavros Niarchos Foundation (F.X.C.). We thank Maarten Mennes for Figures 1 and 2 , and all our colleagues and friends for helpful and stimulating discussion and debate.
PY - 2012/3
Y1 - 2012/3
N2 - The functional MRI (fMRI) community has zealously embraced resting state or intrinsic functional connectivity approaches to mapping brain organization. Having demonstrated their utility for charting the large-scale functional architecture of the brain, the field is now leveraging task-independent methods for the investigation of phenotypic variation and the identification of biomarkers for clinical conditions. Enthusiasm aside, questions regarding the significance and validity of intrinsic brain phenomena remain. Here, we discuss these challenges and outline current developments that, in moving the field toward discovery science, permit a shift from cartography toward a mechanistic understanding of the neural bases of variation in cognition, emotion and behavior.
AB - The functional MRI (fMRI) community has zealously embraced resting state or intrinsic functional connectivity approaches to mapping brain organization. Having demonstrated their utility for charting the large-scale functional architecture of the brain, the field is now leveraging task-independent methods for the investigation of phenotypic variation and the identification of biomarkers for clinical conditions. Enthusiasm aside, questions regarding the significance and validity of intrinsic brain phenomena remain. Here, we discuss these challenges and outline current developments that, in moving the field toward discovery science, permit a shift from cartography toward a mechanistic understanding of the neural bases of variation in cognition, emotion and behavior.
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U2 - 10.1016/j.tics.2012.02.001
DO - 10.1016/j.tics.2012.02.001
M3 - Review article
C2 - 22341211
AN - SCOPUS:84857507183
SN - 1364-6613
VL - 16
SP - 181
EP - 188
JO - Trends in Cognitive Sciences
JF - Trends in Cognitive Sciences
IS - 3
ER -