TY - GEN
T1 - Chronic recordings from the rat spinal cord descending tracts with microwires
AU - Prasad, Abhishek
AU - Sahin, Mesut
PY - 2011
Y1 - 2011
N2 - This study investigated the feasibility of chronically recording descending signals from the rat spinal cord using microwire electrodes. Eight 25m diameter Pt-Ir microwires were implanted in the dorsolateral rubrospinal tract (RST) bilaterally at the c5 level in each of the four adult Long Evans rats trained for food reach-to-grasp task. Signal stability was assessed by calculating the signal-to-noise ratio (SNR) and mean signal amplitude during the four week recording period. The results of ANOVA did not suggest significant difference between sessions for any of the electrodes, indicating stability. Immunohistology suggested minimal tissue response to these microwires during the four week implant period. The results of this study show that microwire electrodes can be used for short-term chronic recordings of signals from the descending motor tracts in experimental animals.
AB - This study investigated the feasibility of chronically recording descending signals from the rat spinal cord using microwire electrodes. Eight 25m diameter Pt-Ir microwires were implanted in the dorsolateral rubrospinal tract (RST) bilaterally at the c5 level in each of the four adult Long Evans rats trained for food reach-to-grasp task. Signal stability was assessed by calculating the signal-to-noise ratio (SNR) and mean signal amplitude during the four week recording period. The results of ANOVA did not suggest significant difference between sessions for any of the electrodes, indicating stability. Immunohistology suggested minimal tissue response to these microwires during the four week implant period. The results of this study show that microwire electrodes can be used for short-term chronic recordings of signals from the descending motor tracts in experimental animals.
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U2 - 10.1109/IEMBS.2011.6090821
DO - 10.1109/IEMBS.2011.6090821
M3 - Conference contribution
C2 - 22254970
AN - SCOPUS:84862606664
SN - 9781424441211
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
SP - 2993
EP - 2996
BT - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
T2 - 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011
Y2 - 30 August 2011 through 3 September 2011
ER -