Classification of polypeptide spectra from rat liver samples

Lit Hsin Loo; John Quinn; James Armitage; Hayley Cordingley; Samuel Roberts; Peter J. Bugelski; Leonid Hrebien; Moshe Kam

Classification of polypeptide spectra from rat liver samples

Lit Hsin Loo, John Quinn, James Armitage, Hayley Cordingley, Samuel Roberts, Peter J. Bugelski, Leonid Hrebien, Moshe Kam

Research output: Contribution to journal › Conference article › peer-review

Abstract

We use clustering-based algorithms to classify polypeptide spectra of treated rat liver samples obtained through surface enhanced laser desorption/ ionization mass spectrometry (SELDI-MS). Variance analysis is used to extract useful features from the high dimensional datasets. The features are then clustered using a hierarchical clustering algorithm based on scaled Euclidean distances. The clusters created are found to be correlated to the toxicity of the rat liver samples.

Original language	English (US)
Pages (from-to)	139-140
Number of pages	2
Journal	Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
State	Published - 2002
Externally published	Yes
Event	IEEE 28th Annual Northeast Bioengineering Conference - Philadelphia, PA, United States Duration: Apr 20 2002 → Apr 21 2002

All Science Journal Classification (ASJC) codes

General Chemical Engineering
Bioengineering

Keywords

Hepatotoxicity
Hierarchical clustering
Matrix assisted laser desorption/ionization
Polypeptide spectra
Predictive toxicology
SELDI

Cite this

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title = "Classification of polypeptide spectra from rat liver samples",

abstract = "We use clustering-based algorithms to classify polypeptide spectra of treated rat liver samples obtained through surface enhanced laser desorption/ ionization mass spectrometry (SELDI-MS). Variance analysis is used to extract useful features from the high dimensional datasets. The features are then clustered using a hierarchical clustering algorithm based on scaled Euclidean distances. The clusters created are found to be correlated to the toxicity of the rat liver samples.",

keywords = "Hepatotoxicity, Hierarchical clustering, Matrix assisted laser desorption/ionization, Polypeptide spectra, Predictive toxicology, SELDI",

author = "Loo, {Lit Hsin} and John Quinn and James Armitage and Hayley Cordingley and Samuel Roberts and Bugelski, {Peter J.} and Leonid Hrebien and Moshe Kam",

year = "2002",

language = "English (US)",

pages = "139--140",

journal = "Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC",

issn = "1071-121X",

note = "IEEE 28th Annual Northeast Bioengineering Conference ; Conference date: 20-04-2002 Through 21-04-2002",

}

TY - JOUR

T1 - Classification of polypeptide spectra from rat liver samples

AU - Loo, Lit Hsin

AU - Quinn, John

AU - Armitage, James

AU - Cordingley, Hayley

AU - Roberts, Samuel

AU - Bugelski, Peter J.

AU - Hrebien, Leonid

AU - Kam, Moshe

PY - 2002

Y1 - 2002

N2 - We use clustering-based algorithms to classify polypeptide spectra of treated rat liver samples obtained through surface enhanced laser desorption/ ionization mass spectrometry (SELDI-MS). Variance analysis is used to extract useful features from the high dimensional datasets. The features are then clustered using a hierarchical clustering algorithm based on scaled Euclidean distances. The clusters created are found to be correlated to the toxicity of the rat liver samples.

AB - We use clustering-based algorithms to classify polypeptide spectra of treated rat liver samples obtained through surface enhanced laser desorption/ ionization mass spectrometry (SELDI-MS). Variance analysis is used to extract useful features from the high dimensional datasets. The features are then clustered using a hierarchical clustering algorithm based on scaled Euclidean distances. The clusters created are found to be correlated to the toxicity of the rat liver samples.

KW - Hepatotoxicity

KW - Hierarchical clustering

KW - Matrix assisted laser desorption/ionization

KW - Polypeptide spectra

KW - Predictive toxicology

KW - SELDI

UR - http://www.scopus.com/inward/record.url?scp=84948434908&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84948434908&partnerID=8YFLogxK

M3 - Conference article

AN - SCOPUS:84948434908

SN - 1071-121X

SP - 139

EP - 140

JO - Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC

JF - Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC

T2 - IEEE 28th Annual Northeast Bioengineering Conference

Y2 - 20 April 2002 through 21 April 2002

ER -

Classification of polypeptide spectra from rat liver samples

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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