CLASSIFICATION OF RNA SEQUENCES WITH SUPPORT VECTOR MACHINES

Support vector machines (SVMs) are a state-of-the-art machine learning tool widely used in speech recognition, image processing and biological sequence analysis. An essential step in SVMs is to devise a kernel function to compute the similarity between two data points. In this chapter we review recent advances of using SVMs for RNA classification. In particular we present a new kernel that takes advantage of both global and local structural information in RNAs and uses the information together to classify RNAs. Experimental results demonstrate the good performance of the new kernel and show that it outperforms existing kernels when applied to classifying non-coding RNA sequences.