Closed-loop stimulations of hypoglossal nerve using its spontaneous activity as the feedback signal

Mesut Sahin, Dominique M. Durand

Research output: Contribution to journalConference articlepeer-review

2 Scopus citations

Abstract

Electrical recruitment of the upper airway (UAW) muscles has been attempted as a treatment method for Obstructive Sleep Apnea (OSA). Hypoglossal nerve (HG) and genioglossus muscle (GG) stimulations have given successful results in OSA patients. A reliable method for detection of obstructions is needed to trigger the stimulations in phase with respiration during obstructive breaths before this technique can be used clinically. In this paper, we investigate the possibility of closed-loop HG nerve stimulations using its spontaneous activity for detection of obstructions in a dog model. The activity of the HG nerve is recorded with chronically implanted nerve cuff electrodes in sleeping dogs while a force is being applied onto the submental region to collapse the airways. The increase in the phasic HG activity as a response to the submental force is used to trigger the stimulations. Closed-loop stimulations are shown to relieve the UAWs from the collapsing effect of the submental force.

Original languageEnglish (US)
Pages (from-to)2526-2527
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume5
StatePublished - Dec 1 1998
Externally publishedYes
EventProceedings of the 1998 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 4 (of 6) - Hong Kong, China
Duration: Oct 29 1998Nov 1 1998

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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