Co-existent activity patterns in inhibitory neuronal networks with short-term synaptic depression

Amitabha Bose, Victoria Booth

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A network of two neurons mutually coupled through inhibitory synapses that display short-term synaptic depression is considered. We show that synaptic depression expands the number of possible activity patterns that the network can display and allows for co-existence of different patterns. Specifically, the network supports different types of n-m anti-phase firing patterns, where one neuron fires n spikes followed by the other neuron firing m spikes. When maximal synaptic conductances are identical, n-n anti-phase firing patterns are obtained and there are conductance intervals over which different pairs of these solutions co-exist. The multitude of n-m anti-phase patterns and their co-existence are not found when the synapses are non-depressing. Geometric singular perturbation methods for dynamical systems are applied to the original eight-dimensional model system to derive a set of one-dimensional conditions for the existence and co-existence of different anti-phase solutions. The generality and validity of these conditions are demonstrated through numerical simulations utilizing the Hodgkin-Huxley and Morris-Lecar neuronal models.

Original languageEnglish (US)
Pages (from-to)42-54
Number of pages13
JournalJournal of Theoretical Biology
Volume272
Issue number1
DOIs
StatePublished - Mar 7 2011

All Science Journal Classification (ASJC) codes

  • Statistics and Probability
  • Modeling and Simulation
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Agricultural and Biological Sciences(all)
  • Applied Mathematics

Keywords

  • Dynamical systems
  • Periodic orbit
  • Synaptic depression

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