Collagen-based fiber-gel constructs engineered for Schwann cell guidance and adult axon growth

M. L. Siriwardane, K. E. DeRosa, Bryan Pfister

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Adult Schwann cells cultured within three-dimensional (3D) collagen-based nervous tissue constructs demonstrated downstream migration and potential use in the contact-guidance of regenerating adult dorsal root ganglia (DRG) axons. Type I collagen extracted from rat tail tendons was used to prepare collagen dispersions for wet spinning micron-size collagen fibers. Biodegradable poly-L-lactic acid (PLLA) and wet-spun collagen fibers containing various extracellular matrix (ECM) proteins were used to evaluate Schwann cell guidance and survival of primary adult rat DRGs, which presents a more realistic model for studying regenerative processes.

Original languageEnglish (US)
Title of host publication2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011
DOIs
StatePublished - Jun 16 2011
Event37th Annual Northeast Bioengineering Conference, NEBEC 2011 - Troy, NY, United States
Duration: Apr 1 2011Apr 3 2011

Publication series

Name2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011

Other

Other37th Annual Northeast Bioengineering Conference, NEBEC 2011
CountryUnited States
CityTroy, NY
Period4/1/114/3/11

All Science Journal Classification (ASJC) codes

  • Bioengineering

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