Collagen-based substrates with tunable strength for soft tissue engineering

Vivek A. Kumar, Jeffrey M. Caves, Carolyn A. Haller, Erbin Dai, Liying Liu, Stephanie Grainger, Elliot L. Chaikof

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Through the use of mechanical reinforcement of collagen matrices, mechanically strong and compliant 3D tissue mimetic scaffolds can be generated that act as scaffolds for soft tissue engineering. Collagen has been widely used for the development of materials for repair, augmentation or replacement of damaged or diseased tissue. Herein we describe a facile method for the layer-by-layer fabrication of robust planar collagen fiber constructs. Collagen gels cast in a phosphate buffer were dried to form dense collagen mats. Subsequent gels were layered and dried atop mats to create multilayer constructs possessing a range of tunable strengths (0.5-11 MPa) and stiffness (1-115 MPa). Depending on processing conditions and crosslinking of constructs, strain to failure ranged between 9 to 48%. Collagen mats were constructed into hernia patches that prevented hernia recurrence in Wistar rats.

Original languageEnglish (US)
Pages (from-to)1193-1202
Number of pages10
JournalBiomaterials Science
Volume1
Issue number11
DOIs
StatePublished - Nov 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Materials Science(all)

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