TY - JOUR
T1 - Common and distinct neurofunctional representations of core and social disgust in the brain
T2 - Coordinate-based and network meta-analyses
AU - Gan, Xianyang
AU - Zhou, Xinqi
AU - Li, Jialin
AU - Jiao, Guojuan
AU - Jiang, Xi
AU - Biswal, Bharat
AU - Yao, Shuxia
AU - Klugah-Brown, Benjamin
AU - Becker, Benjamin
N1 - Funding Information:
This work was supported by the National Key Research and Development Program of China ( 2018YFA0701400 ); and the National Natural Science Foundation of China (NSFC, 61871420 ).
Funding Information:
This work was supported by the National Key Research and Development Program of China (2018YFA0701400); and the National Natural Science Foundation of China (NSFC, 61871420). We would also like to thank Zonglin He and Qian Tao from Jinan University (China) for their kind help with resolving some data analyzing issues.
Publisher Copyright:
© 2022 Elsevier Ltd
PY - 2022/4
Y1 - 2022/4
N2 - Disgust represents a multifaceteddefensive-avoidanceresponse. On the behavioral level, the response includes withdrawal and a disgust-specific facial expression. While both serve the avoidance of pathogens, the latter additionally transmits social-communicative information. Given that common and distinct brain representation of the primary defensive-avoidance response (core disgust) and encoding of the social-communicative signal (social disgust) remain debated, we employed neuroimaging meta-analyses to (1) determine brain systems generally engaged in disgust processing, and (2) segregate common and distinct brain systems for core and social disgust. Disgust processing, in general, engaged a bilateral network encompassing the insula, amygdala, occipital and prefrontal regions. Core disgust evoked stronger reactivity in left-lateralized threat detection and defensive response network including amygdala, occipital and frontal regions, while social disgust engaged a right-lateralized superior temporal-frontal network involved in social cognition. Anterior insula, inferior frontal and fusiform regions were commonly engaged during core and social disgust, suggesting a shared neurofunctional basis. We demonstrate a common and distinct neural basis of primary disgust responses and encoding of associated social-communicative signals.
AB - Disgust represents a multifaceteddefensive-avoidanceresponse. On the behavioral level, the response includes withdrawal and a disgust-specific facial expression. While both serve the avoidance of pathogens, the latter additionally transmits social-communicative information. Given that common and distinct brain representation of the primary defensive-avoidance response (core disgust) and encoding of the social-communicative signal (social disgust) remain debated, we employed neuroimaging meta-analyses to (1) determine brain systems generally engaged in disgust processing, and (2) segregate common and distinct brain systems for core and social disgust. Disgust processing, in general, engaged a bilateral network encompassing the insula, amygdala, occipital and prefrontal regions. Core disgust evoked stronger reactivity in left-lateralized threat detection and defensive response network including amygdala, occipital and frontal regions, while social disgust engaged a right-lateralized superior temporal-frontal network involved in social cognition. Anterior insula, inferior frontal and fusiform regions were commonly engaged during core and social disgust, suggesting a shared neurofunctional basis. We demonstrate a common and distinct neural basis of primary disgust responses and encoding of associated social-communicative signals.
KW - Activation likelihood estimation (ALE)
KW - Amygdala
KW - Defensive-avoidance response
KW - Disgust
KW - FMRI
KW - Face
KW - Insula
KW - Meta-analysis
KW - Meta-analytic connectivity modeling (MACM)
KW - Social cognition
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U2 - 10.1016/j.neubiorev.2022.104553
DO - 10.1016/j.neubiorev.2022.104553
M3 - Review article
C2 - 35122784
AN - SCOPUS:85124230237
SN - 0149-7634
VL - 135
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
M1 - 104553
ER -