@article{81e7c472646145a3a2a7f0a4c4e84c79,
title = "Common variants in MMP20 at 11q22.2 predispose to 11q deletion and neuroblastoma risk",
abstract = "MYCN amplification and 11q deletion are two inversely correlated prognostic factors of poor outcome in neuroblastoma. Here we identify common variants at 11q22.2 within MMP20 that associate with neuroblastoma cases harboring 11q deletion (rs10895322), using GWAS in 113 European-American cases and 5109 ancestry-matched controls. The association is replicated in 44 independent cases and 1902 controls. Our study yields novel insights into the genetic underpinnings of neuroblastoma, demonstrating that the inherited common variants reported contribute to the origin of intra-tumor genetic heterogeneity in neuroblastoma.",
author = "Xiao Chang and Yan Zhao and Cuiping Hou and Joseph Glessner and Lee McDaniel and Diamond, {Maura A.} and Kelly Thomas and Jin Li and Zhi Wei and Yichuan Liu and Yiran Guo and Mentch, {Frank D.} and Haijun Qiu and Cecilia Kim and Perry Evans and Zalman Vaksman and Diskin, {Sharon J.} and Attiyeh, {Edward F.} and Patrick Sleiman and Maris, {John M.} and Hakon Hakonarson",
note = "Funding Information: We thank the patients and their families for their participation in this study. The study was supported by Institutional Development Funds from the CHOP, and by NIH grants U01HG006830 (H.H.) and R01CA124709 (J.M.M.). This work was also supported in part by US National Institutes of Health grants RC1MD004418 to the TARGET consortium, and CA98543 and U10 CA180899 to the COG (J.M.M.). In addition, this project was funded in part with Federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E (J.M.M.). The content of this publication does not necessarily reflect the views of policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government. Publisher Copyright: {\textcopyright} 2017 The Author(s).",
year = "2017",
month = dec,
day = "1",
doi = "10.1038/s41467-017-00408-8",
language = "English (US)",
volume = "8",
journal = "Nature communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}