Complementary near-infrared and raman chemical imaging of pharmaceutical thin films

Jackeline I. Jérez Rozo, Anna Zarow, Bo Zhou, Rodolfo Pinal, Zafar Iqbal, Rodolfo J. Romañach

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Complementary near-infrared (NIR) and Raman mapping techniques have been used to study the distribution of drug particles suspended in a polymeric film. The film configuration was used with the goal of maintaining a drug with a particle size of less than 10 μm in a nonagglomerated form and to satisfy two commonly encountered pharmaceutical needs: enhanced dissolution rate of poorly soluble drugs and the content uniformity of drugs administered in low doses. A total of four film batches were prepared for this study using hydroxypropyl methylcellulose (HPMC) with griseofulvin as the active pharmaceutical ingredient. The NIR method analyzed a film area of 3 × 2.6 mm, whereas Raman mapping analyzed an area of 10 × 10 μm, and every sample was analyzed by the two methods. The second derivative transform removed baseline variations in the NIR spectra and provided differentiation between the two components. NIR chemical imaging did not identify clusters larger than 0.05 mm. Raman analysis identified areas rich in griseofulvin or HPMC, which were used to develop a partial least squares discriminant analysis method to determine drug or polymer distribution throughout the film.

Original languageEnglish (US)
Pages (from-to)4888-4895
Number of pages8
JournalJournal of Pharmaceutical Sciences
Volume100
Issue number11
DOIs
StatePublished - Nov 2011

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Content uniformity
  • Image analysis
  • Near-infrared spectroscopy
  • Polymeric drug carrier
  • Polymers
  • Raman spectroscopy

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