Complex optically computed phase microscopy for label-free sub-cellular imaging

Xuan Liu, Yuwei Liu, Shupei Yu, Yuanwei Zhang

Research output: Contribution to journalArticlepeer-review


In this study, we investigated a complex optically computed phase microscopy (complex-OCPM) technology. Based on a low coherence interferometer and an innovative optical computation approach, the complex-OCPM imaging system achieves depth resolved quantitative phase measurement. Particularly, the complex-OCPM imaging system directly measures the complex amplitude of the optical field emerging from the sample, extracts the phase as the argument of a complex signal, and achieves a high spatial resolution in phase imaging. We evaluated the performance of complex-OCPM imaging using resolution targets and live cells. Our results show that the complex-OCPM system achieves quantitative phase imaging with sub-cellular resolution on label-free cells.

Original languageEnglish (US)
Pages (from-to)793-800
Number of pages8
JournalOSA Continuum
Issue number4
StatePublished - Apr 15 2023

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Electrical and Electronic Engineering


Dive into the research topics of 'Complex optically computed phase microscopy for label-free sub-cellular imaging'. Together they form a unique fingerprint.

Cite this