Abstract
Complex patterns in neuronal networks emerge from the cooperative activity of the participating neurons, synaptic connectivity and network topology. Several neuron types exhibit complex intrinsic dynamics due to the presence of nonlinearities and multiple time scales. In this paper we extend previous work on hyperexcitability of neuronal networks, a hallmark of epileptic brain seizure generation, which results from the net imbalance between excitation and inhibition and the ability of certain neuron types to exhibit abrupt transitions between low and high firing frequency regimes as the levels of recurrent AMPA excitation change. We examine the effect of different topologies and connection delays on the hyperexcitability phenomenon in networks having recurrent synaptic AMPA (fast) excitation (in the absence of synaptic inhibition) and demonstrate the emergence of additional time scales.
Original language | English (US) |
---|---|
Pages (from-to) | 71-82 |
Number of pages | 12 |
Journal | Theoretical Computer Science |
Volume | 633 |
DOIs | |
State | Published - Jun 20 2016 |
All Science Journal Classification (ASJC) codes
- Theoretical Computer Science
- General Computer Science
Keywords
- Neuronal networks
- Synchronization