TY - JOUR
T1 - Comprehensive in vitro studies of novel sol gel-derived Zr4+/Zn2+ co-substituted bioactive glass with enhanced biological properties for bone healing
AU - Moghanian, Amirhossein
AU - Zohourfazeli, Mohammadamin
AU - Haji Mahdi Tajer, Mahzad
AU - Miri, Amir K.
N1 - Publisher Copyright:
© 2021 Elsevier B.V.
PY - 2021/8/15
Y1 - 2021/8/15
N2 - The synergetic osteogenic effects of zirconium (Zr) and zinc (Zn) along with bioactive glasses (BGs) have been proposed for bone implantation. We incorporated Zn into Zr-modified 58S-BG (Zr content: 5 mol. %) and characterized the structural, morphological, biological, and antibacterial properties of the proposed composite using various methods. Energy-dispersive X-ray spectroscopy analysis showed the calcium to phosphate ratio of ~1.68, after one week of conditioning in SBF. Biological assays also revealed a higher stimulating effect of the biomaterial composite on the proliferation and osteogenic response of osteoblast-like cells compared to only BGs. Antibacterial studies showed ~ 5-10% reduction in resistivity of methicillin-resistant Staphylococcus Aureus (MRSA) bacteria against the biomaterial composite in comparison to the control specimen. The incorporation of Zn led to potential outlooks for implantations instead of Zn-free specimens since they promoted the cell proliferation of MC3T3 cells as well as resistivity toward MRSA bacteria.
AB - The synergetic osteogenic effects of zirconium (Zr) and zinc (Zn) along with bioactive glasses (BGs) have been proposed for bone implantation. We incorporated Zn into Zr-modified 58S-BG (Zr content: 5 mol. %) and characterized the structural, morphological, biological, and antibacterial properties of the proposed composite using various methods. Energy-dispersive X-ray spectroscopy analysis showed the calcium to phosphate ratio of ~1.68, after one week of conditioning in SBF. Biological assays also revealed a higher stimulating effect of the biomaterial composite on the proliferation and osteogenic response of osteoblast-like cells compared to only BGs. Antibacterial studies showed ~ 5-10% reduction in resistivity of methicillin-resistant Staphylococcus Aureus (MRSA) bacteria against the biomaterial composite in comparison to the control specimen. The incorporation of Zn led to potential outlooks for implantations instead of Zn-free specimens since they promoted the cell proliferation of MC3T3 cells as well as resistivity toward MRSA bacteria.
KW - Bioactive glass
KW - Bone healing
KW - Sol-gel processes
KW - Zinc
KW - ZrO
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U2 - 10.1016/j.jnoncrysol.2021.120887
DO - 10.1016/j.jnoncrysol.2021.120887
M3 - Article
AN - SCOPUS:85105577415
SN - 0022-3093
VL - 566
JO - Journal of Non-Crystalline Solids
JF - Journal of Non-Crystalline Solids
M1 - 120887
ER -