Abstract
The synergetic osteogenic effects of zirconium (Zr) and zinc (Zn) along with bioactive glasses (BGs) have been proposed for bone implantation. We incorporated Zn into Zr-modified 58S-BG (Zr content: 5 mol. %) and characterized the structural, morphological, biological, and antibacterial properties of the proposed composite using various methods. Energy-dispersive X-ray spectroscopy analysis showed the calcium to phosphate ratio of ~1.68, after one week of conditioning in SBF. Biological assays also revealed a higher stimulating effect of the biomaterial composite on the proliferation and osteogenic response of osteoblast-like cells compared to only BGs. Antibacterial studies showed ~ 5-10% reduction in resistivity of methicillin-resistant Staphylococcus Aureus (MRSA) bacteria against the biomaterial composite in comparison to the control specimen. The incorporation of Zn led to potential outlooks for implantations instead of Zn-free specimens since they promoted the cell proliferation of MC3T3 cells as well as resistivity toward MRSA bacteria.
| Original language | English (US) |
|---|---|
| Article number | 120887 |
| Journal | Journal of Non-Crystalline Solids |
| Volume | 566 |
| DOIs | |
| State | Published - Aug 15 2021 |
| Externally published | Yes |
All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Condensed Matter Physics
- Materials Chemistry
Keywords
- Bioactive glass
- Bone healing
- Sol-gel processes
- Zinc
- ZrO