TY - GEN
T1 - Computational simulation of the deformation of neuronal cells
AU - Cao, Guoxin
AU - Zhou, You
AU - Lee, Jeong Soon
AU - Lim, Jung Yul
AU - Ganpule, Shailesh
AU - Chandra, Namas
PY - 2010
Y1 - 2010
N2 - A numerical simulation (finite element method (FEM)) is used to determine the local mechanical response of a neuron based on the real neuron geometry. The real 3D geometry of a neuron can be constructed from the 2D confocal image stack which is taken per micron along the thickness direction from the top surface of neuron to the substrate. By matching the simulated deformation of the neuron with the measured results from the confocal microscopy images, the relative strength of the neuron components can be determined based on the reverse analysis of FEM. Then, the neuron local mechanical response and the relationship between the local response and the global applied deformation can be obtained, which will be the first step of building the mechanical injury model of neuron.
AB - A numerical simulation (finite element method (FEM)) is used to determine the local mechanical response of a neuron based on the real neuron geometry. The real 3D geometry of a neuron can be constructed from the 2D confocal image stack which is taken per micron along the thickness direction from the top surface of neuron to the substrate. By matching the simulated deformation of the neuron with the measured results from the confocal microscopy images, the relative strength of the neuron components can be determined based on the reverse analysis of FEM. Then, the neuron local mechanical response and the relationship between the local response and the global applied deformation can be obtained, which will be the first step of building the mechanical injury model of neuron.
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U2 - 10.1115/IMECE2010-37949
DO - 10.1115/IMECE2010-37949
M3 - Conference contribution
AN - SCOPUS:84881442302
SN - 9780791844267
T3 - ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)
SP - 179
EP - 180
BT - ASME 2010 International Mechanical Engineering Congress and Exposition, IMECE 2010
T2 - ASME 2010 International Mechanical Engineering Congress and Exposition, IMECE 2010
Y2 - 12 November 2010 through 18 November 2010
ER -