Consensus structure prediction for RNA alignments

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

RNA secondary structure prediction has been studied for quite awhile. Many minimum free energy (MFE) methods have been developed for predicting the secondary structures of single RNA sequences, such as mfold [1], RNAfold [2], MPGAfold [3], as well as recent tools presented in the literature [4, 5]. However, the accuracy of predicted structures is far from perfect. As evaluated by Gardner and Giegerich [6], the accuracy of the MFE methods for single sequences is 73% when averaged over many different RNAs.

Original languageEnglish (US)
Title of host publicationBiological Data Mining
PublisherCRC Press
Pages1-26
Number of pages26
ISBN (Electronic)9781420086850
ISBN (Print)9781420086843
StatePublished - Jan 1 2009

All Science Journal Classification (ASJC) codes

  • Computer Science(all)
  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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