Consensus structure prediction for RNA alignments

Junilda Spirollari, Jason T.L. Wang

Research output: Chapter in Book/Report/Conference proceedingChapter


RNA secondary structure prediction has been studied for quite awhile. Many minimum free energy (MFE) methods have been developed for predicting the secondary structures of single RNA sequences, such as mfold [1], RNAfold [2], MPGAfold [3], as well as recent tools presented in the literature [4, 5]. However, the accuracy of predicted structures is far from perfect. As evaluated by Gardner and Giegerich [6], the accuracy of the MFE methods for single sequences is 73% when averaged over many different RNAs.

Original languageEnglish (US)
Title of host publicationBiological Data Mining
PublisherCRC Press
Number of pages26
ISBN (Electronic)9781420086850
ISBN (Print)9781420086843
StatePublished - Jan 1 2009

All Science Journal Classification (ASJC) codes

  • General Computer Science
  • General Agricultural and Biological Sciences
  • General Biochemistry, Genetics and Molecular Biology


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