Continuous preparation of polymer coated drug crystals by solid hollow fiber membrane-based cooling crystallization

Dengyue Chen, Dhananjay Singh, Kamalesh K. Sirkar, Robert Pfeffer

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

A facile way to continuously coat drug crystals with a polymer is needed in controlled drug release. Conventional polymer coating methods have disadvantages: high energy consumption, low productivity, batch processing. A novel method for continuous polymer coating of drug crystals based on solid hollow fiber cooling crystallization (SHFCC) is introduced here. The drug acting as the host particle and the polymer for coating are Griseofulvin (GF) and Eudragit RL100, respectively. The polymer's cloud point temperature in its acetone solution was determined by UV spectrophotometry. An acetone solution of the polymer containing the drug in solution as well as undissolved drug crystals in suspension were pumped through the tube side of the SHFCC device; a cold liquid was circulated in the shell side to rapidly cool down the feed solution-suspension in the hollow-fiber lumen. The polymer precipitated from the solution and coated the suspended crystals due to rapid temperature reduction and heterogeneous nucleation; crystals formed from the solution were also coated by the polymer. Characterizations by scanning electron microscopy, thermogravimetric analysis, laser diffraction spectroscopy, X-ray diffraction, Raman spectroscopy, and dissolution tests show that a uniformly coated, free-flowing drug/product can be obtained under appropriate operating conditions without losing the drug's pharmaceutical properties and controlled release characteristics.

Original languageEnglish (US)
Pages (from-to)395-402
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume499
Issue number1-2
DOIs
StatePublished - Feb 29 2016

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Drug crystals
  • Membrane-based cooling crystallization
  • Polymer coating
  • Solid hollow fiber

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