TY - GEN
T1 - Continuous production of polymer coated drug crystals, submicron particles, and nanoparticles by hollow fiber membrane-based cooling and anti-solvent crystallization
AU - Chen, D.
AU - Singh, D.
AU - Jin, C.
AU - Sirkar, K.
AU - Pfeffer, R.
PY - 2017
Y1 - 2017
N2 - Currently, no technique is available to continuously film coat fine and nano-sized drug particles with a polymer to produce large amounts of free-flowing coated particles. We have adapted both the solid hollow fiber cooling crystallization (SHFCC) and the porous hollow fiber membrane-based anti-solvent crystallization (PHFAC) techniques to continuously produce polymer-coated micro-particles, nanoparticles, and drug crystals. Controlled cooling or addition of an anti-solvent allows for polymer nucleation on the surface of the particles and the formation of a thin polymer film around the particles, the thickness of which can be varied depending on the operating conditions. Furthermore, scale-up of both techniques can be easily accomplished by using a larger SHFCC or PHFAC module containing a larger number of solid or porous hollow fiber membranes (HFMs).
AB - Currently, no technique is available to continuously film coat fine and nano-sized drug particles with a polymer to produce large amounts of free-flowing coated particles. We have adapted both the solid hollow fiber cooling crystallization (SHFCC) and the porous hollow fiber membrane-based anti-solvent crystallization (PHFAC) techniques to continuously produce polymer-coated micro-particles, nanoparticles, and drug crystals. Controlled cooling or addition of an anti-solvent allows for polymer nucleation on the surface of the particles and the formation of a thin polymer film around the particles, the thickness of which can be varied depending on the operating conditions. Furthermore, scale-up of both techniques can be easily accomplished by using a larger SHFCC or PHFAC module containing a larger number of solid or porous hollow fiber membranes (HFMs).
KW - Anti-solvent crystallization
KW - Continuous polymer coating of particles
KW - Cooling crystallization
KW - Hollow fiber membranes
KW - Nanoparticles and drug crystals
UR - http://www.scopus.com/inward/record.url?scp=85029366539&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85029366539&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85029366539
T3 - Advanced Materials - TechConnect Briefs 2017
SP - 52
EP - 55
BT - Biotech, Biomaterials and Biomedical - TechConnect Briefs 2017
A2 - Case, Fiona
A2 - Laudon, Matthew
A2 - Case, Fiona
A2 - Romanowicz, Bart
PB - TechConnect
T2 - 11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo, and the 2017 National SBIR/STTR Conference
Y2 - 14 May 2017 through 17 May 2017
ER -