Abstract
Currently, no technique is available to continuously film coat fine and nano-sized drug particles with a polymer to produce large amounts of free-flowing coated particles. We have adapted both the solid hollow fiber cooling crystallization (SHFCC) and the porous hollow fiber membrane-based anti-solvent crystallization (PHFAC) techniques to continuously produce polymer-coated micro-particles, nanoparticles, and drug crystals. Controlled cooling or addition of an anti-solvent allows for polymer nucleation on the surface of the particles and the formation of a thin polymer film around the particles, the thickness of which can be varied depending on the operating conditions. Furthermore, scale-up of both techniques can be easily accomplished by using a larger SHFCC or PHFAC module containing a larger number of solid or porous hollow fiber membranes (HFMs).
Original language | English (US) |
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Title of host publication | Biotech, Biomaterials and Biomedical - TechConnect Briefs 2017 |
Editors | Fiona Case, Matthew Laudon, Fiona Case, Bart Romanowicz |
Publisher | TechConnect |
Pages | 52-55 |
Number of pages | 4 |
Volume | 3 |
ISBN (Electronic) | 9780998878201 |
State | Published - Jan 1 2017 |
Event | 11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo, and the 2017 National SBIR/STTR Conference - Washington, United States Duration: May 14 2017 → May 17 2017 |
Other
Other | 11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo, and the 2017 National SBIR/STTR Conference |
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Country/Territory | United States |
City | Washington |
Period | 5/14/17 → 5/17/17 |
All Science Journal Classification (ASJC) codes
- Fuel Technology
- Surfaces, Coatings and Films
- Biotechnology
- Fluid Flow and Transfer Processes