Continuous production of polymer coated drug crystals, submicron particles, and nanoparticles by hollow fiber membrane-based cooling and anti-solvent crystallization

D. Chen, D. Singh, C. Jin, Kamalesh Sirkar, R. Pfeffer

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Currently, no technique is available to continuously film coat fine and nano-sized drug particles with a polymer to produce large amounts of free-flowing coated particles. We have adapted both the solid hollow fiber cooling crystallization (SHFCC) and the porous hollow fiber membrane-based anti-solvent crystallization (PHFAC) techniques to continuously produce polymer-coated micro-particles, nanoparticles, and drug crystals. Controlled cooling or addition of an anti-solvent allows for polymer nucleation on the surface of the particles and the formation of a thin polymer film around the particles, the thickness of which can be varied depending on the operating conditions. Furthermore, scale-up of both techniques can be easily accomplished by using a larger SHFCC or PHFAC module containing a larger number of solid or porous hollow fiber membranes (HFMs).

Original languageEnglish (US)
Title of host publicationBiotech, Biomaterials and Biomedical - TechConnect Briefs 2017
EditorsFiona Case, Matthew Laudon, Fiona Case, Bart Romanowicz
PublisherTechConnect
Pages52-55
Number of pages4
Volume3
ISBN (Electronic)9780998878201
StatePublished - Jan 1 2017
Event11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo, and the 2017 National SBIR/STTR Conference - Washington, United States
Duration: May 14 2017May 17 2017

Other

Other11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo, and the 2017 National SBIR/STTR Conference
CountryUnited States
CityWashington
Period5/14/175/17/17

All Science Journal Classification (ASJC) codes

  • Fuel Technology
  • Surfaces, Coatings and Films
  • Biotechnology
  • Fluid Flow and Transfer Processes

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