@inproceedings{ad69ab661acd4664b40fb0fa5cc4cac8,
title = "Continuous production of polymer coated drug crystals, submicron particles, and nanoparticles by hollow fiber membrane-based cooling and anti-solvent crystallization",
abstract = "Currently, no technique is available to continuously film coat fine and nano-sized drug particles with a polymer to produce large amounts of free-flowing coated particles. We have adapted both the solid hollow fiber cooling crystallization (SHFCC) and the porous hollow fiber membrane-based anti-solvent crystallization (PHFAC) techniques to continuously produce polymer-coated micro-particles, nanoparticles, and drug crystals. Controlled cooling or addition of an anti-solvent allows for polymer nucleation on the surface of the particles and the formation of a thin polymer film around the particles, the thickness of which can be varied depending on the operating conditions. Furthermore, scale-up of both techniques can be easily accomplished by using a larger SHFCC or PHFAC module containing a larger number of solid or porous hollow fiber membranes (HFMs).",
keywords = "Anti-solvent crystallization, Continuous polymer coating of particles, Cooling crystallization, Hollow fiber membranes, Nanoparticles and drug crystals",
author = "D. Chen and D. Singh and C. Jin and K. Sirkar and R. Pfeffer",
year = "2017",
language = "English (US)",
series = "Advanced Materials - TechConnect Briefs 2017",
publisher = "TechConnect",
pages = "52--55",
editor = "Fiona Case and Matthew Laudon and Fiona Case and Bart Romanowicz",
booktitle = "Biotech, Biomaterials and Biomedical - TechConnect Briefs 2017",
note = "11th Annual TechConnect World Innovation Conference and Expo, Held Jointly with the 20th Annual Nanotech Conference and Expo, and the 2017 National SBIR/STTR Conference ; Conference date: 14-05-2017 Through 17-05-2017",
}