Controlled Angiogenesis in Peptide Nanofiber Composite Hydrogels

Navindee C. Wickremasinghe, Vivek A. Kumar, Siyu Shi, Jeffrey D. Hartgerink

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

Multidomain peptide (MDP) nanofibers create scaffolds that can present bioactive cues to promote biological responses. Orthogonal self-assembly of MDPs and growth-factor-loaded liposomes generate supramolecular composite hydrogels. These composites can act as delivery vehicles with time-controlled release. Here we examine the controlled release of placental growth factor-1 (PlGF-1) for its ability to induce angiogenic responses. PlGF-1 was loaded either in MDP matrices or within liposomes bound inside MDP matrices. Scaffolds showed expected rapid infiltration of macrophages. When released through liposomes incorporated in MDP gels (MDP(Lipo)), PlGF-1 modulates HUVEC VEGF receptor activation in vitro and robust vessel formation in vivo. These loaded MDP(Lipo) hydrogels induce a high level of growth-factor-mediated neovascular maturity. MDP(Lipo) hydrogels offer a biocompatible and injectable platform to tailor drug delivery and treat ischemic tissue diseases.

Original languageEnglish (US)
Pages (from-to)845-854
Number of pages10
JournalACS Biomaterials Science and Engineering
Volume1
Issue number9
DOIs
StatePublished - Sep 14 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

Keywords

  • PlGF-1
  • angiogenesis
  • cellular infiltration
  • liposomal encapsulation
  • multidomain peptide
  • self-assembly

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