Cortical thickness abnormalities in patients with first episode psychosis: a meta-analysis of psychoradiologic studies and replication in an independent sample

Keren Wen; Youjin Zhao; Qiyong Gong; Ziyu Zhu; Qian Li; Nanfang Pan; Shiqin Fu; Joaquim Radua; Eduard Vieta; Poornima Kumar; Graham J. Kemp; Bharat B. Biswal

doi:10.1093/psyrad/kkab015

Cortical thickness abnormalities in patients with first episode psychosis: a meta-analysis of psychoradiologic studies and replication in an independent sample

Keren Wen, Youjin Zhao, Qiyong Gong, Ziyu Zhu, Qian Li, Nanfang Pan, Shiqin Fu, Joaquim Radua, Eduard Vieta, Poornima Kumar, Graham J. Kemp, Bharat B. Biswal

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Background: Abnormalities of cortical thickness (CTh) in patients with their first episode psychosis (FEP) have been frequently reported, but findings are inconsistent. Objective: To define the most consistent CTh changes in patients with FEP by meta-analysis of published whole-brain studies. Methods: The meta-analysis used seed-based d mapping (SDM) software to obtain the most prominent regional CTh changes in FEP, and meta-regression analyses to explore the effects of demographics and clinical characteristics. The meta-analysis results were verified in an independent sample of 142 FEP patients and 142 age- and sex-matched healthy controls (HCs), using both a vertex-wise and a region of interest analysis, with multiple comparisons correction. Results: The meta-analysis identified lower CTh in the right middle temporal cortex (MTC) extending to superior temporal cortex (STC), insula, and anterior cingulate cortex (ACC) in FEP compared with HCs. No significant correlations were identified between CTh alterations and demographic or clinical variables. These results were replicated in the independent dataset analysis. Conclusion: This study identifies a robust pattern of cortical abnormalities in FEP and extends understanding of gray matter abnormalities and pathological mechanisms in FEP.

Original language	English (US)
Pages (from-to)	185-198
Number of pages	14
Journal	Psychoradiology
Volume	1
Issue number	4
DOIs	https://doi.org/10.1093/psyrad/kkab015
State	Published - Dec 1 2021

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging
Psychiatry and Mental health
Artificial Intelligence
Psychology (miscellaneous)
Clinical Psychology
Clinical Neurology
Neuroscience (miscellaneous)

Keywords

cortical thickness
early psychosis
first episode psychosis
meta-analysis
psychoradiology
seed-based d mapping

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10.1093/psyrad/kkab015

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@article{652ac3366a644fb7b072a9436e372783,

title = "Cortical thickness abnormalities in patients with first episode psychosis: a meta-analysis of psychoradiologic studies and replication in an independent sample",

abstract = "Background: Abnormalities of cortical thickness (CTh) in patients with their first episode psychosis (FEP) have been frequently reported, but findings are inconsistent. Objective: To define the most consistent CTh changes in patients with FEP by meta-analysis of published whole-brain studies. Methods: The meta-analysis used seed-based d mapping (SDM) software to obtain the most prominent regional CTh changes in FEP, and meta-regression analyses to explore the effects of demographics and clinical characteristics. The meta-analysis results were verified in an independent sample of 142 FEP patients and 142 age- and sex-matched healthy controls (HCs), using both a vertex-wise and a region of interest analysis, with multiple comparisons correction. Results: The meta-analysis identified lower CTh in the right middle temporal cortex (MTC) extending to superior temporal cortex (STC), insula, and anterior cingulate cortex (ACC) in FEP compared with HCs. No significant correlations were identified between CTh alterations and demographic or clinical variables. These results were replicated in the independent dataset analysis. Conclusion: This study identifies a robust pattern of cortical abnormalities in FEP and extends understanding of gray matter abnormalities and pathological mechanisms in FEP.",

keywords = "cortical thickness, early psychosis, first episode psychosis, meta-analysis, psychoradiology, seed-based d mapping",

author = "Keren Wen and Youjin Zhao and Qiyong Gong and Ziyu Zhu and Qian Li and Nanfang Pan and Shiqin Fu and Joaquim Radua and Eduard Vieta and Poornima Kumar and Kemp, {Graham J.} and Biswal, {Bharat B.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2021. Published by Oxford University Press on behalf of West China School of Medicine/West China Hospital (WCSM/WCH) of Sichuan University. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.",

year = "2021",

month = dec,

day = "1",

doi = "10.1093/psyrad/kkab015",

language = "English (US)",

volume = "1",

pages = "185--198",

journal = "Psychoradiology",

issn = "2634-4416",

publisher = "Oxford University Press",

number = "4",

}

TY - JOUR

T1 - Cortical thickness abnormalities in patients with first episode psychosis

T2 - a meta-analysis of psychoradiologic studies and replication in an independent sample

AU - Wen, Keren

AU - Zhao, Youjin

AU - Gong, Qiyong

AU - Zhu, Ziyu

AU - Li, Qian

AU - Pan, Nanfang

AU - Fu, Shiqin

AU - Radua, Joaquim

AU - Vieta, Eduard

AU - Kumar, Poornima

AU - Kemp, Graham J.

AU - Biswal, Bharat B.

N1 - Publisher Copyright: © The Author(s) 2021. Published by Oxford University Press on behalf of West China School of Medicine/West China Hospital (WCSM/WCH) of Sichuan University. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

PY - 2021/12/1

Y1 - 2021/12/1

N2 - Background: Abnormalities of cortical thickness (CTh) in patients with their first episode psychosis (FEP) have been frequently reported, but findings are inconsistent. Objective: To define the most consistent CTh changes in patients with FEP by meta-analysis of published whole-brain studies. Methods: The meta-analysis used seed-based d mapping (SDM) software to obtain the most prominent regional CTh changes in FEP, and meta-regression analyses to explore the effects of demographics and clinical characteristics. The meta-analysis results were verified in an independent sample of 142 FEP patients and 142 age- and sex-matched healthy controls (HCs), using both a vertex-wise and a region of interest analysis, with multiple comparisons correction. Results: The meta-analysis identified lower CTh in the right middle temporal cortex (MTC) extending to superior temporal cortex (STC), insula, and anterior cingulate cortex (ACC) in FEP compared with HCs. No significant correlations were identified between CTh alterations and demographic or clinical variables. These results were replicated in the independent dataset analysis. Conclusion: This study identifies a robust pattern of cortical abnormalities in FEP and extends understanding of gray matter abnormalities and pathological mechanisms in FEP.

AB - Background: Abnormalities of cortical thickness (CTh) in patients with their first episode psychosis (FEP) have been frequently reported, but findings are inconsistent. Objective: To define the most consistent CTh changes in patients with FEP by meta-analysis of published whole-brain studies. Methods: The meta-analysis used seed-based d mapping (SDM) software to obtain the most prominent regional CTh changes in FEP, and meta-regression analyses to explore the effects of demographics and clinical characteristics. The meta-analysis results were verified in an independent sample of 142 FEP patients and 142 age- and sex-matched healthy controls (HCs), using both a vertex-wise and a region of interest analysis, with multiple comparisons correction. Results: The meta-analysis identified lower CTh in the right middle temporal cortex (MTC) extending to superior temporal cortex (STC), insula, and anterior cingulate cortex (ACC) in FEP compared with HCs. No significant correlations were identified between CTh alterations and demographic or clinical variables. These results were replicated in the independent dataset analysis. Conclusion: This study identifies a robust pattern of cortical abnormalities in FEP and extends understanding of gray matter abnormalities and pathological mechanisms in FEP.

KW - cortical thickness

KW - early psychosis

KW - first episode psychosis

KW - meta-analysis

KW - psychoradiology

KW - seed-based d mapping

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U2 - 10.1093/psyrad/kkab015

DO - 10.1093/psyrad/kkab015

M3 - Article

AN - SCOPUS:85132474097

SN - 2634-4416

VL - 1

SP - 185

EP - 198

JO - Psychoradiology

JF - Psychoradiology

IS - 4

ER -

Cortical thickness abnormalities in patients with first episode psychosis: a meta-analysis of psychoradiologic studies and replication in an independent sample

Abstract

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