Dependence of firing pattern on intrinsic ionic conductances: Sensitive and insensitive combinations

Mark S. Goldman; Jorge Golowasch; Eve Marder; L. F. Abbott

doi:10.1016/S0925-2312(00)00155-7

Dependence of firing pattern on intrinsic ionic conductances: Sensitive and insensitive combinations

Mark S. Goldman, Jorge Golowasch, Eve Marder, L. F. Abbott

Research output: Contribution to journal › Conference article › peer-review

7 Scopus citations

Abstract

We construct maps of the intrinsic firing state (silent, tonically firing, or bursting) of a model neuron as a function of its maximal ionic conductances. The firing properties vary significantly only in response to changes in particular, sensitive combinations of conductances that may serve as targets for neuromodulation. Less sensitive combinations define directions along which neuronal conductances may drift without triggering significant changes in firing activity. This suggests that neurons may have similar functional properties despite widely varying conductance densities. (C) 2000 Elsevier Science B.V. All rights reserved.

Original language	English (US)
Pages (from-to)	141-146
Number of pages	6
Journal	Neurocomputing
Volume	32-33
DOIs	https://doi.org/10.1016/S0925-2312(00)00155-7
State	Published - Jun 2000
Externally published	Yes
Event	The 8th Annual Computational Neuroscience Meeting (CNS'99) - Pittsburgh, PA, USA Duration: Jul 18 1999 → Jul 22 1999

All Science Journal Classification (ASJC) codes

Computer Science Applications
Cognitive Neuroscience
Artificial Intelligence

Keywords

Activity-dependent regulation
Conductance-based model
Neuromodulation
Stomatogastric ganglion

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10.1016/S0925-2312(00)00155-7

Cite this

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title = "Dependence of firing pattern on intrinsic ionic conductances: Sensitive and insensitive combinations",

abstract = "We construct maps of the intrinsic firing state (silent, tonically firing, or bursting) of a model neuron as a function of its maximal ionic conductances. The firing properties vary significantly only in response to changes in particular, sensitive combinations of conductances that may serve as targets for neuromodulation. Less sensitive combinations define directions along which neuronal conductances may drift without triggering significant changes in firing activity. This suggests that neurons may have similar functional properties despite widely varying conductance densities. (C) 2000 Elsevier Science B.V. All rights reserved.",

keywords = "Activity-dependent regulation, Conductance-based model, Neuromodulation, Stomatogastric ganglion",

author = "Goldman, {Mark S.} and Jorge Golowasch and Eve Marder and Abbott, {L. F.}",

note = "Funding Information: This work was supported by Grants MH 46742, NSF-IBN-9817194, and the W.M. Keck Foundation. ; The 8th Annual Computational Neuroscience Meeting (CNS'99) ; Conference date: 18-07-1999 Through 22-07-1999",

year = "2000",

month = jun,

doi = "10.1016/S0925-2312(00)00155-7",

language = "English (US)",

volume = "32-33",

pages = "141--146",

journal = "Neurocomputing",

issn = "0925-2312",

publisher = "Elsevier",

}

TY - JOUR

T1 - Dependence of firing pattern on intrinsic ionic conductances

T2 - The 8th Annual Computational Neuroscience Meeting (CNS'99)

AU - Goldman, Mark S.

AU - Golowasch, Jorge

AU - Marder, Eve

AU - Abbott, L. F.

N1 - Funding Information: This work was supported by Grants MH 46742, NSF-IBN-9817194, and the W.M. Keck Foundation.

PY - 2000/6

Y1 - 2000/6

N2 - We construct maps of the intrinsic firing state (silent, tonically firing, or bursting) of a model neuron as a function of its maximal ionic conductances. The firing properties vary significantly only in response to changes in particular, sensitive combinations of conductances that may serve as targets for neuromodulation. Less sensitive combinations define directions along which neuronal conductances may drift without triggering significant changes in firing activity. This suggests that neurons may have similar functional properties despite widely varying conductance densities. (C) 2000 Elsevier Science B.V. All rights reserved.

AB - We construct maps of the intrinsic firing state (silent, tonically firing, or bursting) of a model neuron as a function of its maximal ionic conductances. The firing properties vary significantly only in response to changes in particular, sensitive combinations of conductances that may serve as targets for neuromodulation. Less sensitive combinations define directions along which neuronal conductances may drift without triggering significant changes in firing activity. This suggests that neurons may have similar functional properties despite widely varying conductance densities. (C) 2000 Elsevier Science B.V. All rights reserved.

KW - Activity-dependent regulation

KW - Conductance-based model

KW - Neuromodulation

KW - Stomatogastric ganglion

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U2 - 10.1016/S0925-2312(00)00155-7

DO - 10.1016/S0925-2312(00)00155-7

M3 - Conference article

AN - SCOPUS:18544401895

SN - 0925-2312

VL - 32-33

SP - 141

EP - 146

JO - Neurocomputing

JF - Neurocomputing

Y2 - 18 July 1999 through 22 July 1999

ER -

Dependence of firing pattern on intrinsic ionic conductances: Sensitive and insensitive combinations

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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