Dependence of firing pattern on intrinsic ionic conductances: Sensitive and insensitive combinations

Mark S. Goldman, Jorge Golowasch, Eve Marder, L. F. Abbott

Research output: Contribution to journalConference articlepeer-review

5 Scopus citations

Abstract

We construct maps of the intrinsic firing state (silent, tonically firing, or bursting) of a model neuron as a function of its maximal ionic conductances. The firing properties vary significantly only in response to changes in particular, sensitive combinations of conductances that may serve as targets for neuromodulation. Less sensitive combinations define directions along which neuronal conductances may drift without triggering significant changes in firing activity. This suggests that neurons may have similar functional properties despite widely varying conductance densities. (C) 2000 Elsevier Science B.V. All rights reserved.

Original languageEnglish (US)
Pages (from-to)141-146
Number of pages6
JournalNeurocomputing
Volume32-33
DOIs
StatePublished - Jun 2000
Externally publishedYes
EventThe 8th Annual Computational Neuroscience Meeting (CNS'99) - Pittsburgh, PA, USA
Duration: Jul 18 1999Jul 22 1999

All Science Journal Classification (ASJC) codes

  • Computer Science Applications
  • Cognitive Neuroscience
  • Artificial Intelligence

Keywords

  • Activity-dependent regulation
  • Conductance-based model
  • Neuromodulation
  • Stomatogastric ganglion

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