Dependence of functional vulnerabilities to the parameters of the caspase molecular network

I. Habibi, A. Abdi, E. S. Emamian

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper a systems biology framework for generalized fault diagnosis in the caspase signaling network of biomolecules is studied. This novel method is capable of identifying critical molecules whose dysfunction can affect the network function detrimentally. The generalized vulnerabilities defined and computed in the paper quantify the role of molecules in a complex network. Impact of network input activities and multiple faults are studied as well. The results and methods are useful for quantitative analysis of functional impacts of individual or a group of molecules on the overall performance of molecular signaling networks.

Original languageEnglish (US)
Title of host publication2011 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2011
DOIs
StatePublished - Dec 1 2011
Event2011 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2011 - Brooklyn, NY, United States
Duration: Dec 10 2011Dec 10 2011

Publication series

Name2011 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2011

Other

Other2011 IEEE Signal Processing in Medicine and Biology Symposium, SPMB 2011
CountryUnited States
CityBrooklyn, NY
Period12/10/1112/10/11

All Science Journal Classification (ASJC) codes

  • Signal Processing
  • Biomedical Engineering
  • Medicine(all)

Keywords

  • cell signaling
  • fault diagnosis
  • molecular networks
  • molecular systems biology
  • vulnerability

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