Depth-resolved blood oxygen saturation assessment using spectroscopic common-path fourier domain optical coherence tomography

Xuan Liu, Jin U. Kang

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Although spectroscopic optical coherence tomography (OCT) has been shown to be a promising method for measuring blood oxygen saturation with high-spatial resolution and accuracy, there are several technical issues that need to be addressed before it could become a practical method. In this letter, we have attempted to address two issues that could significantly improve the quantitative assessment of blood oxygen saturation level. First, we have implemented a spectral normalization technique to eliminate the spectral modulation induced by the wavelength- distance-dependent point spread function (PSF) of OCT's. Second,to reduce the spectral speckle noise due to the highly scattering blood, we have implemented a spatial low-pass filter to the 2-D OCT dataset consisting of spectra obtained at different lateral positions. We have assessed the effectiveness of these methods using common-pathOCTsystem. Results showed that we were able to extract unambiguous depth-resolved, SO2 -dependent spectroscopic information from 1-D and 2-D OCT images, which could be used to accurately assess the SO2 level.

Original languageEnglish (US)
Pages (from-to)2572-2575
Number of pages4
JournalIEEE Transactions on Biomedical Engineering
Volume57
Issue number10 PART 2
DOIs
StatePublished - Oct 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Keywords

  • Oxygen saturation
  • Spectroscopic optical coherence tomography (SOCT)

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