TY - GEN
T1 - Design and characterization of a controlled wet spinning device for collagen fiber fabrication for neural tissue engineering
AU - DeRosa, K. E.
AU - Siriwardane, M. L.
AU - Pfister, B. J.
PY - 2011
Y1 - 2011
N2 - Type I collagen was extruded into well-defined fibers using a novel controlled wet spinning device. The device significantly improved the yield of collagen fibers on the micron scale. Collagen scaffold materials fabricated from the device will provide contact-guided growth of neuronal cultures. Fibers composed of different weight percentages, 75, 2, and 3.4 wt% collagen dispersions, were used to validate Schwann cell alignment along the fibers. Interestingly, the different concentrations of extruded collagen dispersions demonstrated unique morphologies and directed growth patterns of Schwann cells.
AB - Type I collagen was extruded into well-defined fibers using a novel controlled wet spinning device. The device significantly improved the yield of collagen fibers on the micron scale. Collagen scaffold materials fabricated from the device will provide contact-guided growth of neuronal cultures. Fibers composed of different weight percentages, 75, 2, and 3.4 wt% collagen dispersions, were used to validate Schwann cell alignment along the fibers. Interestingly, the different concentrations of extruded collagen dispersions demonstrated unique morphologies and directed growth patterns of Schwann cells.
UR - http://www.scopus.com/inward/record.url?scp=79958693796&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79958693796&partnerID=8YFLogxK
U2 - 10.1109/NEBC.2011.5778585
DO - 10.1109/NEBC.2011.5778585
M3 - Conference contribution
AN - SCOPUS:79958693796
SN - 9781612848273
T3 - 2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011
BT - 2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011
T2 - 37th Annual Northeast Bioengineering Conference, NEBEC 2011
Y2 - 1 April 2011 through 3 April 2011
ER -