Design and characterization of a controlled wet spinning device for collagen fiber fabrication for neural tissue engineering

K. E. DeRosa, M. L. Siriwardane, Bryan Pfister

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Type I collagen was extruded into well-defined fibers using a novel controlled wet spinning device. The device significantly improved the yield of collagen fibers on the micron scale. Collagen scaffold materials fabricated from the device will provide contact-guided growth of neuronal cultures. Fibers composed of different weight percentages, 75, 2, and 3.4 wt% collagen dispersions, were used to validate Schwann cell alignment along the fibers. Interestingly, the different concentrations of extruded collagen dispersions demonstrated unique morphologies and directed growth patterns of Schwann cells.

Original languageEnglish (US)
Title of host publication2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011
DOIs
StatePublished - Jun 16 2011
Event37th Annual Northeast Bioengineering Conference, NEBEC 2011 - Troy, NY, United States
Duration: Apr 1 2011Apr 3 2011

Other

Other37th Annual Northeast Bioengineering Conference, NEBEC 2011
CountryUnited States
CityTroy, NY
Period4/1/114/3/11

All Science Journal Classification (ASJC) codes

  • Bioengineering

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