Designing Biomaterials for 3D Printing

Murat Guvendiren, Joseph Molde, Rosane M.D. Soares, Joachim Kohn

Research output: Contribution to journalReview articlepeer-review

586 Scopus citations


Three-dimensional (3D) printing is becoming an increasingly common technique to fabricate scaffolds and devices for tissue engineering applications. This is due to the potential of 3D printing to provide patient-specific designs, high structural complexity, rapid on-demand fabrication at a low-cost. One of the major bottlenecks that limits the widespread acceptance of 3D printing in biomanufacturing is the lack of diversity in "biomaterial inks". Printability of a biomaterial is determined by the printing technique. Although a wide range of biomaterial inks including polymers, ceramics, hydrogels and composites have been developed, the field is still struggling with processing of these materials into self-supporting devices with tunable mechanics, degradation, and bioactivity. This review aims to highlight the past and recent advances in biomaterial ink development and design considerations moving forward. A brief overview of 3D printing technologies focusing on ink design parameters is also included.

Original languageEnglish (US)
Pages (from-to)1679-1693
Number of pages15
JournalACS Biomaterials Science and Engineering
Issue number10
StatePublished - Oct 10 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering


  • additive manufacturing
  • ceramic
  • hydrogel
  • polymers
  • rapid prototyping
  • tissue engineering


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