Designing Decellularized Extracellular Matrix-Based Bioinks for 3D Bioprinting

Alperen Abaci, Murat Guvendiren

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

3D bioprinting is an emerging technology to fabricate tissues and organs by precisely positioning cells into 3D structures using printable cell-laden formulations known as bioinks. Various bioinks are utilized in 3D bioprinting applications; however, developing the perfect bioink to fabricate constructs with biomimetic microenvironment and mechanical properties that are similar to native tissues is a challenging task. In recent years, decellularized extracellular matrix (dECM)-based bioinks have received an increasing attention in 3D bioprinting applications, since they are derived from native tissues and possess unique, complex tissue-specific biochemical properties. This review focuses on designing dECM-based bioinks for tissue and organ bioprinting, including commonly used decellularization and decellularized tissue characterization methods, bioink formulation and characterization, applications of dECM-based bioinks, and most recent advancements in dECM-based bioink design.

Original languageEnglish (US)
Article number2000734
JournalAdvanced Healthcare Materials
Volume9
Issue number24
DOIs
StatePublished - Dec 16 2020

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science

Keywords

  • additive manufacturing
  • biofabrication
  • decellularization
  • tissue engineering

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