Abstract
Nanocarrier-based antibody targeting is a promising modality in therapeutic and diagnostic oncology. Single-walled carbon nanotubes (SWNTs) exhibit two unique optical properties that can be exploited for these applications, strong Raman signal for cancer cell detection and near-infrared (NIR) absorbance for selective photothermal ablation of tumors. In the present study, we constructed a HER2 IgY-SWNT complex and demonstrated its dual functionality for both detection and selective destruction of cancer cells in an in vitro model consisting of HER2-expressing SK-BR-3 cells, and HER2-negative MCF-7 cells.
Original language | English (US) |
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Title of host publication | Recent Advances in Nanotechnology |
Publisher | Apple Academic Press |
Pages | 108-123 |
Number of pages | 16 |
ISBN (Electronic) | 9781466558465 |
ISBN (Print) | 9781926692739 |
State | Published - Jan 1 2011 |
All Science Journal Classification (ASJC) codes
- General Chemistry
- General Engineering
Keywords
- Atomic force microscopy
- Immunohistochemistry
- Nanomedicine
- Near-infrared
- Single-walled carbon nanotubes