Detection and selective destruction of breast cancer cells

Yan Xiao, Xiugong Gao, Oleh Taratula, Stephen Treado, Aaron Urbas, R. David Holbrook, Richard E. Cavicchi, C. Thomas Avedisian, Somenath Mitra, Ronak Savla, Paul D. Wagner, Sudhir Srivastava, Huixin He

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Nanocarrier-based antibody targeting is a promising modality in therapeutic and diagnostic oncology. Single-walled carbon nanotubes (SWNTs) exhibit two unique optical properties that can be exploited for these applications, strong Raman signal for cancer cell detection and near-infrared (NIR) absorbance for selective photothermal ablation of tumors. In the present study, we constructed a HER2 IgY-SWNT complex and demonstrated its dual functionality for both detection and selective destruction of cancer cells in an in vitro model consisting of HER2-expressing SK-BR-3 cells, and HER2-negative MCF-7 cells.

Original languageEnglish (US)
Title of host publicationRecent Advances in Nanotechnology
PublisherApple Academic Press
Pages108-123
Number of pages16
ISBN (Electronic)9781466558465
ISBN (Print)9781926692739
StatePublished - Jan 1 2011

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Engineering(all)

Keywords

  • Atomic force microscopy
  • Immunohistochemistry
  • Nanomedicine
  • Near-infrared
  • Single-walled carbon nanotubes

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