Detection and selective destruction of breast cancer cells

Yan Xiao; Xiugong Gao; Oleh Taratula; Stephen Treado; Aaron Urbas; R. David Holbrook; Richard E. Cavicchi; C. Thomas Avedisian; Somenath Mitra; Ronak Savla; Paul D. Wagner; Sudhir Srivastava; Huixin He

Detection and selective destruction of breast cancer cells

Yan Xiao
, Xiugong Gao
, Oleh Taratula
, Stephen Treado
, Aaron Urbas
, R. David Holbrook
, Richard E. Cavicchi
, C. Thomas Avedisian
, Somenath Mitra
, Ronak Savla
, Paul D. Wagner
, Sudhir Srivastava
, Huixin He

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Nanocarrier-based antibody targeting is a promising modality in therapeutic and diagnostic oncology. Single-walled carbon nanotubes (SWNTs) exhibit two unique optical properties that can be exploited for these applications, strong Raman signal for cancer cell detection and near-infrared (NIR) absorbance for selective photothermal ablation of tumors. In the present study, we constructed a HER2 IgY-SWNT complex and demonstrated its dual functionality for both detection and selective destruction of cancer cells in an in vitro model consisting of HER2-expressing SK-BR-3 cells, and HER2-negative MCF-7 cells.

Original language	English (US)
Title of host publication	Recent Advances in Nanotechnology
Publisher	Apple Academic Press
Pages	108-123
Number of pages	16
ISBN (Electronic)	9781466558465
ISBN (Print)	9781926692739
State	Published - Jan 1 2011

All Science Journal Classification (ASJC) codes

General Chemistry
General Engineering

Keywords

Atomic force microscopy
Immunohistochemistry
Nanomedicine
Near-infrared
Single-walled carbon nanotubes

Cite this

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title = "Detection and selective destruction of breast cancer cells",

abstract = "Nanocarrier-based antibody targeting is a promising modality in therapeutic and diagnostic oncology. Single-walled carbon nanotubes (SWNTs) exhibit two unique optical properties that can be exploited for these applications, strong Raman signal for cancer cell detection and near-infrared (NIR) absorbance for selective photothermal ablation of tumors. In the present study, we constructed a HER2 IgY-SWNT complex and demonstrated its dual functionality for both detection and selective destruction of cancer cells in an in vitro model consisting of HER2-expressing SK-BR-3 cells, and HER2-negative MCF-7 cells.",

keywords = "Atomic force microscopy, Immunohistochemistry, Nanomedicine, Near-infrared, Single-walled carbon nanotubes",

author = "Yan Xiao and Xiugong Gao and Oleh Taratula and Stephen Treado and Aaron Urbas and Holbrook, \{R. David\} and Cavicchi, \{Richard E.\} and Avedisian, \{C. Thomas\} and Somenath Mitra and Ronak Savla and Wagner, \{Paul D.\} and Sudhir Srivastava and Huixin He",

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TY - CHAP

T1 - Detection and selective destruction of breast cancer cells

AU - Xiao, Yan

AU - Gao, Xiugong

AU - Taratula, Oleh

AU - Treado, Stephen

AU - Urbas, Aaron

AU - Holbrook, R. David

AU - Cavicchi, Richard E.

AU - Avedisian, C. Thomas

AU - Mitra, Somenath

AU - Savla, Ronak

AU - Wagner, Paul D.

AU - Srivastava, Sudhir

AU - He, Huixin

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Nanocarrier-based antibody targeting is a promising modality in therapeutic and diagnostic oncology. Single-walled carbon nanotubes (SWNTs) exhibit two unique optical properties that can be exploited for these applications, strong Raman signal for cancer cell detection and near-infrared (NIR) absorbance for selective photothermal ablation of tumors. In the present study, we constructed a HER2 IgY-SWNT complex and demonstrated its dual functionality for both detection and selective destruction of cancer cells in an in vitro model consisting of HER2-expressing SK-BR-3 cells, and HER2-negative MCF-7 cells.

AB - Nanocarrier-based antibody targeting is a promising modality in therapeutic and diagnostic oncology. Single-walled carbon nanotubes (SWNTs) exhibit two unique optical properties that can be exploited for these applications, strong Raman signal for cancer cell detection and near-infrared (NIR) absorbance for selective photothermal ablation of tumors. In the present study, we constructed a HER2 IgY-SWNT complex and demonstrated its dual functionality for both detection and selective destruction of cancer cells in an in vitro model consisting of HER2-expressing SK-BR-3 cells, and HER2-negative MCF-7 cells.

KW - Atomic force microscopy

KW - Immunohistochemistry

KW - Nanomedicine

KW - Near-infrared

KW - Single-walled carbon nanotubes

UR - https://www.scopus.com/pages/publications/85059577554

UR - https://www.scopus.com/pages/publications/85059577554#tab=citedBy

M3 - Chapter

SN - 9781926692739

SP - 108

EP - 123

BT - Recent Advances in Nanotechnology

PB - Apple Academic Press

ER -

Detection and selective destruction of breast cancer cells

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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