Detection of heterogeneously expressed genes in cancer

Scott Haney, Moshe Kam, Leonid Hrebien

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Several mutations have been found to be heterogeneous throughout cancer samples. As an example, approximately 20% of lung cancer cases have a mutation in the proto-oncogene RAS. In order to specifically test for heterogeneous mutations we introduce a new test that measures differences between quantiles. It will be shown that this test can achieve larger power values than a previously published test by Coombes et al. when sample sizes are small (10-20 samples) and the probability of mutation is small (10%-40%). When applied to two publicly available mi-croarray data sets our method also produces lists of results that are 12% and 27% the size of those produced by Coombes et al.

Original languageEnglish (US)
Title of host publicationGENSIPS'08 - 6th IEEE International Workshop on Genomic Signal Processing and Statistics
DOIs
StatePublished - Sep 17 2008
Externally publishedYes
Event6th IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS'08 - Phoenix, AZ, United States
Duration: Jun 8 2008Jun 10 2008

Publication series

NameGENSIPS'08 - 6th IEEE International Workshop on Genomic Signal Processing and Statistics

Other

Other6th IEEE International Workshop on Genomic Signal Processing and Statistics, GENSIPS'08
CountryUnited States
CityPhoenix, AZ
Period6/8/086/10/08

All Science Journal Classification (ASJC) codes

  • Genetics
  • Signal Processing
  • Electrical and Electronic Engineering
  • Statistics, Probability and Uncertainty

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