TY - JOUR
T1 - Development and Applications of Liquid Sample Desorption Electrospray Ionization Mass Spectrometry
AU - Zheng, Qiuling
AU - Chen, Hao
N1 - Publisher Copyright:
Copyright © 2016 by Annual Reviews. All rights reserved.
PY - 2016/6/12
Y1 - 2016/6/12
N2 - Desorption electrospray ionization mass spectrometry (DESI-MS) is a recent advance in the field of analytical chemistry. This review surveys the development of liquid sample DESI-MS (LS-DESI-MS), a variant form of DESI-MS that focuses on fast analysis of liquid samples, and its novel analy-tical applications in bioanalysis, proteomics, and reaction kinetics. Due to the capability of directly ionizing liquid samples, liquid sample DESI (LS-DESI) has been successfully used to couple MS with various analytical techniques, such as microfluidics, microextraction, electrochemistry, and chromatography. This review also covers these hyphenated techniques. In addition, several closely related ionization methods, including transmission mode DESI, thermally assisted DESI, and continuous flow-extractive DESI, are briefly discussed. The capabilities of LS-DESI extend and-or complement the utilities of traditional DESI and electrospray ionization and will find extensive and valuable analytical application in the future.
AB - Desorption electrospray ionization mass spectrometry (DESI-MS) is a recent advance in the field of analytical chemistry. This review surveys the development of liquid sample DESI-MS (LS-DESI-MS), a variant form of DESI-MS that focuses on fast analysis of liquid samples, and its novel analy-tical applications in bioanalysis, proteomics, and reaction kinetics. Due to the capability of directly ionizing liquid samples, liquid sample DESI (LS-DESI) has been successfully used to couple MS with various analytical techniques, such as microfluidics, microextraction, electrochemistry, and chromatography. This review also covers these hyphenated techniques. In addition, several closely related ionization methods, including transmission mode DESI, thermally assisted DESI, and continuous flow-extractive DESI, are briefly discussed. The capabilities of LS-DESI extend and-or complement the utilities of traditional DESI and electrospray ionization and will find extensive and valuable analytical application in the future.
KW - Chromatography
KW - Disulfide bond reduction
KW - Electrochemistry
KW - Kinetics
KW - LS-DESI-MS
KW - Proteomics
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U2 - 10.1146/annurev-anchem-071015-041620
DO - 10.1146/annurev-anchem-071015-041620
M3 - Review article
AN - SCOPUS:84975500040
SN - 1936-1327
VL - 9
SP - 411
EP - 448
JO - Annual Review of Analytical Chemistry
JF - Annual Review of Analytical Chemistry
ER -