Development and Applications of Liquid Sample Desorption Electrospray Ionization Mass Spectrometry

Qiuling Zheng, Hao Chen

Research output: Contribution to journalReview articlepeer-review

20 Scopus citations


Desorption electrospray ionization mass spectrometry (DESI-MS) is a recent advance in the field of analytical chemistry. This review surveys the development of liquid sample DESI-MS (LS-DESI-MS), a variant form of DESI-MS that focuses on fast analysis of liquid samples, and its novel analy-tical applications in bioanalysis, proteomics, and reaction kinetics. Due to the capability of directly ionizing liquid samples, liquid sample DESI (LS-DESI) has been successfully used to couple MS with various analytical techniques, such as microfluidics, microextraction, electrochemistry, and chromatography. This review also covers these hyphenated techniques. In addition, several closely related ionization methods, including transmission mode DESI, thermally assisted DESI, and continuous flow-extractive DESI, are briefly discussed. The capabilities of LS-DESI extend and-or complement the utilities of traditional DESI and electrospray ionization and will find extensive and valuable analytical application in the future.

Original languageEnglish (US)
Pages (from-to)411-448
Number of pages38
JournalAnnual Review of Analytical Chemistry
StatePublished - Jun 12 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry


  • Chromatography
  • Disulfide bond reduction
  • Electrochemistry
  • Kinetics
  • Proteomics


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