We developed the ground work for a computational model that can simulate blast explosions, blast wave-human body interaction, human head and brain biomechanics, and coupling between the brain and cerebrospinal fluids. The main development task was focused on the adaptation of the in-house code, CoBi, to model compressible flows with shock waves, Finite Element Method (FEM) modeling of biomechanics, and for modeling fluid-structures interaction (FSI) problems. To validate the computational model, a head surrogate will be designed for the experiments of head exposure in blast conditions. The actual construction of the head surrogate is taking several iterations due to the complexity of building such a bio-mechanically correct physical model. The construction of the head surrogate is an ongoing effort. Once the head surrogate is complete, it will be tested in the shock tube lab.