Digital Light Processing Bioprinting Advances for Microtissue Models

Hossein Goodarzi Hosseinabadi, Elvan Dogan, Amir K. Miri, Leonid Ionov

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations


Digital light processing (DLP) bioprinting has been widely introduced as a fast and robust biofabrication method in tissue engineering. The technique holds a great promise for creating tissue models because it can replicate the resolution and complexity of natural tissues and constructs. A DLP system projects 2D images onto layers of bioink using a digital photomask. The resolution of DLP bioprinting strongly depends on the characteristics of the projected light and the photo-cross-linking response of the bioink microenvironment. In this review, we present a summary of DLP fundamentals with a focus on bioink properties, photoinitiator selection, and light characteristics in resolution of bioprinted constructs. A simple guideline is provided for bioengineers interested in using DLP platforms and customizing technical specifications for its design. The literature review reveals the promising future of DLP bioprinting for disease modeling and biofabrication.

Original languageEnglish (US)
Pages (from-to)1381-1395
Number of pages15
JournalACS Biomaterials Science and Engineering
Issue number4
StatePublished - Apr 11 2022

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering


  • bioprinter design
  • digital light processing
  • tissue engineering
  • vascularized models


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