Direct Evidence for the Origin of Bis-Gold Intermediates: Probing Gold Catalysis with Mass Spectrometry

Mei Lu, Yijin Su, Pengyi Zhao, Xiaohan Ye, Yi Cai, Xiaodong Shi, Eric Masson, Fengyao Li, J. Larry Campbell, Hao Chen

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Gold-catalyzed alkyne hydration was studied by using in situ reacting mass spectrometry (MS) technology. By monitoring the reaction process in solution under different conditions (regular and very diluted catalyst concentrations, different pH values) and examining the reaction occurrence in the early reaction stage (1–2 ms after mixing) with MS, we collected a series of experimental evidence to support that the bis-gold complex is a potential key reaction intermediate. Furthermore, both experimental and computational studies confirmed that the σ,π-bis-gold complexes are not active intermediates toward nucleophilic addition. Instead, formation of geminally diaurated complex C is crucial for this catalytic process.

Original languageEnglish (US)
Pages (from-to)2144-2150
Number of pages7
JournalChemistry - A European Journal
Volume24
Issue number9
DOIs
StatePublished - Feb 9 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Organic Chemistry

Keywords

  • desorption electrospray ionization mass spectrometry (DESI-MS)
  • gold catalysis
  • hydration
  • mass spectrometry

Fingerprint Dive into the research topics of 'Direct Evidence for the Origin of Bis-Gold Intermediates: Probing Gold Catalysis with Mass Spectrometry'. Together they form a unique fingerprint.

Cite this