TY - GEN

T1 - Direct simulation of the migration of leukocytes in pressure driven flow

AU - Quan, Jin

AU - Verdier, Claude

AU - Singh, Pushpendra

AU - Aubry, Nadine

AU - Duperray, Alain

PY - 2006

Y1 - 2006

N2 - We use the direct numerical simulation (DNS) approach to study the motion and deformation of leukocytes in pressure driven flows in a parallel plate channel in the case where there is an adhesion force between the leukocytes and the channel wall and when the adhesion force is absent. Two composite fluid models, consisting of a membrane, cytoplasm and a nucleus, are used to describe leukocytes. The first is the composite-drop model in which the cytoplasm and the nucleus are modeled as fluids, and the second is the drop-rigid-particle model in which the cytoplasm is modeled as a fluid and the nucleus as a rigid particle. The cytoplasm is modeled as a Newtonian fluid. The nucleus in the first model is assumed to be a viscoelastic liquid. The adhesion force is computed using two adhesion force models. In the first model, the adhesion force is given by a potential that varies as the fourth power of the distance between the cell and the adhesive wall. In the second model, the adhesion force is given by the Dembo's kinetic adhesion model. The numerical code is based on the finite element method and the level-set method is used to track the cell membrane position. In the absence of the adhesion force, the equilibrium location of a freely suspended leukocyte in a pressure driven flow in a channel is shown to depend on the ratio of the cell to plasma viscosities. In presence of the adhesion force, the leukocyte is attracted to the layer of endothelial cells and, as it gets closer, it also deforms to get flatter under the shear forces. This deformation, in turn, further increases the adhesion force.

AB - We use the direct numerical simulation (DNS) approach to study the motion and deformation of leukocytes in pressure driven flows in a parallel plate channel in the case where there is an adhesion force between the leukocytes and the channel wall and when the adhesion force is absent. Two composite fluid models, consisting of a membrane, cytoplasm and a nucleus, are used to describe leukocytes. The first is the composite-drop model in which the cytoplasm and the nucleus are modeled as fluids, and the second is the drop-rigid-particle model in which the cytoplasm is modeled as a fluid and the nucleus as a rigid particle. The cytoplasm is modeled as a Newtonian fluid. The nucleus in the first model is assumed to be a viscoelastic liquid. The adhesion force is computed using two adhesion force models. In the first model, the adhesion force is given by a potential that varies as the fourth power of the distance between the cell and the adhesive wall. In the second model, the adhesion force is given by the Dembo's kinetic adhesion model. The numerical code is based on the finite element method and the level-set method is used to track the cell membrane position. In the absence of the adhesion force, the equilibrium location of a freely suspended leukocyte in a pressure driven flow in a channel is shown to depend on the ratio of the cell to plasma viscosities. In presence of the adhesion force, the leukocyte is attracted to the layer of endothelial cells and, as it gets closer, it also deforms to get flatter under the shear forces. This deformation, in turn, further increases the adhesion force.

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M3 - Conference contribution

AN - SCOPUS:33847048180

SN - 0791847500

SN - 9780791847503

T3 - Proceedings of ASME Fluids Engineering Division Summer Meeting 2006, FEDSM2006

SP - 1519

EP - 1526

BT - Proceedings of ASME Fluids Engineering Division Summer Meeting 2006, FEDSM2006

T2 - 2006 ASME Joint U.S.- European Fluids Engineering Division Summer Meeting, FEDSM2006

Y2 - 17 July 2006 through 20 July 2006

ER -