Directed enzyme evolution

Edgardo T. Farinas; Thomas Bulter; Frances H. Arnold

doi:10.1016/S0958-1669(01)00261-0

Directed enzyme evolution

Edgardo T. Farinas, Thomas Bulter, Frances H. Arnold

Research output: Contribution to journal › Review article › peer-review

236 Scopus citations

Abstract

Laboratory evolutionists continue to generate better enzymes for industrial and research applications. Exciting developments include new biocatalysts for enantioselective carbon-carbon bond formation and fatty acid production in plants. Creative contributions to the repertoire of evolutionary methods will ensure further growth in applications and expand the scope and complexity of biological design problems that can be addressed. Researchers are also starting to elucidate mechanisms of enzyme adaptation and natural evolution by testing evolutionary scenarios in the laboratory.

Original language	English (US)
Pages (from-to)	545-551
Number of pages	7
Journal	Current Opinion in Biotechnology
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/S0958-1669(01)00261-0
State	Published - Dec 1 2001
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Biomedical Engineering

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10.1016/S0958-1669(01)00261-0

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title = "Directed enzyme evolution",

abstract = "Laboratory evolutionists continue to generate better enzymes for industrial and research applications. Exciting developments include new biocatalysts for enantioselective carbon-carbon bond formation and fatty acid production in plants. Creative contributions to the repertoire of evolutionary methods will ensure further growth in applications and expand the scope and complexity of biological design problems that can be addressed. Researchers are also starting to elucidate mechanisms of enzyme adaptation and natural evolution by testing evolutionary scenarios in the laboratory.",

author = "Farinas, {Edgardo T.} and Thomas Bulter and Arnold, {Frances H.}",

note = "Funding Information: This work was supported by fellowships from the US National Science Foundation DBI-9807460 (ETF) and the Deutsche Forschungsgemeinschaft (TB). ",

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AU - Bulter, Thomas

AU - Arnold, Frances H.

N1 - Funding Information: This work was supported by fellowships from the US National Science Foundation DBI-9807460 (ETF) and the Deutsche Forschungsgemeinschaft (TB).

PY - 2001/12/1

Y1 - 2001/12/1

N2 - Laboratory evolutionists continue to generate better enzymes for industrial and research applications. Exciting developments include new biocatalysts for enantioselective carbon-carbon bond formation and fatty acid production in plants. Creative contributions to the repertoire of evolutionary methods will ensure further growth in applications and expand the scope and complexity of biological design problems that can be addressed. Researchers are also starting to elucidate mechanisms of enzyme adaptation and natural evolution by testing evolutionary scenarios in the laboratory.

AB - Laboratory evolutionists continue to generate better enzymes for industrial and research applications. Exciting developments include new biocatalysts for enantioselective carbon-carbon bond formation and fatty acid production in plants. Creative contributions to the repertoire of evolutionary methods will ensure further growth in applications and expand the scope and complexity of biological design problems that can be addressed. Researchers are also starting to elucidate mechanisms of enzyme adaptation and natural evolution by testing evolutionary scenarios in the laboratory.

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DO - 10.1016/S0958-1669(01)00261-0

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JO - Current Opinion in Biotechnology

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Directed enzyme evolution

Abstract

All Science Journal Classification (ASJC) codes

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