Directed enzyme evolution

Edgardo T. Farinas, Thomas Bulter, Frances H. Arnold

Research output: Contribution to journalReview articlepeer-review

234 Scopus citations


Laboratory evolutionists continue to generate better enzymes for industrial and research applications. Exciting developments include new biocatalysts for enantioselective carbon-carbon bond formation and fatty acid production in plants. Creative contributions to the repertoire of evolutionary methods will ensure further growth in applications and expand the scope and complexity of biological design problems that can be addressed. Researchers are also starting to elucidate mechanisms of enzyme adaptation and natural evolution by testing evolutionary scenarios in the laboratory.

Original languageEnglish (US)
Pages (from-to)545-551
Number of pages7
JournalCurrent Opinion in Biotechnology
Issue number6
StatePublished - Dec 1 2001
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering


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