TY - JOUR
T1 - Disruption of white matter integrity and its relationship with cognitive function in non-severe traumatic brain injury
AU - Abdullah, Aimi Nadhiah
AU - Ahmad, Asma Hayati
AU - Zakaria, Rahimah
AU - Tamam, Sofina
AU - Abd Hamid, Aini Ismafairus
AU - Chai, Wen Jia
AU - Omar, Hazim
AU - Abdul Rahman, Muhammad Riddha
AU - Fitzrol, Diana Noma
AU - Idris, Zamzuri
AU - Ghani, Abdul Rahman Izaini
AU - Wan Mohamad, Wan Nor Azlen
AU - Mustafar, Faiz
AU - Hanafi, Muhammad Hafiz
AU - Reza, Mohamed Faruque
AU - Umar, Hafidah
AU - Mohd Zulkifly, Mohd Faizal
AU - Ang, Song Yee
AU - Zakaria, Zaitun
AU - Musa, Kamarul Imran
AU - Othman, Azizah
AU - Embong, Zunaina
AU - Sapiai, Nur Asma
AU - Kandasamy, Regunath
AU - Ibrahim, Haidi
AU - Abdullah, Mohd Zaid
AU - Amaruchkul, Kannapha
AU - Valdes-Sosa, Pedro Antonio
AU - Bringas Vega, Maria Luisa
AU - Biswal, Bharat
AU - Songsiri, Jitkomut
AU - Yaacob, Hamwira Sakti
AU - Sumari, Putra
AU - Noh, Nor Azila
AU - Azman, Azlinda
AU - Jamir Singh, Paramjit Singh
AU - Abdullah, Jafri Malin
N1 - Publisher Copyright:
Copyright © 2022 Abdullah, Ahmad, Zakaria, Tamam, Abd Hamid, Chai, Omar, Abdul Rahman, Fitzrol, Idris, Ghani, Wan Mohamad, Mustafar, Hanafi, Reza, Umar, Mohd Zulkifly, Ang, Zakaria, Musa, Othman, Embong, Sapiai, Kandasamy, Ibrahim, Abdullah, Amaruchkul, Valdes-Sosa, Bringas Vega, Biswal, Songsiri, Yaacob, Sumari, Noh, Azman, Jamir Singh and Abdullah.
PY - 2022/10/11
Y1 - 2022/10/11
N2 - Background: Impairment in cognitive function is a recognized outcome of traumatic brain injury (TBI). However, the degree of impairment has variable relationship with TBI severity and time post injury. The underlying pathology is often due to diffuse axonal injury that has been found even in mild TBI. In this study, we examine the state of white matter putative connectivity in patients with non-severe TBI in the subacute phase, i.e., within 10 weeks of injury and determine its relationship with neuropsychological scores. Methods: We conducted a case-control prospective study involving 11 male adult patients with non-severe TBI and an age-matched control group of 11 adult male volunteers. Diffusion MRI scanning and neuropsychological tests were administered within 10 weeks post injury. The difference in fractional anisotropy (FA) values between the patient and control groups was examined using tract-based spatial statistics. The FA values that were significantly different between patients and controls were then correlated with neuropsychological tests in the patient group. Results: Several clusters with peak voxels of significant FA reductions (p < 0.05) in the white matter skeleton were seen in patients compared to the control group. These clusters were located in the superior fronto-occipital fasciculus, superior longitudinal fasciculus, uncinate fasciculus, and cingulum, as well as white matter fibers in the area of genu of corpus callosum, anterior corona radiata, superior corona radiata, anterior thalamic radiation and part of inferior frontal gyrus. Mean global FA magnitude correlated significantly with MAVLT immediate recall scores while matrix reasoning scores correlated positively with FA values in the area of right superior fronto-occipital fasciculus and left anterior corona radiata. Conclusion: The non-severe TBI patients had abnormally reduced FA values in multiple regions compared to controls that correlated with several measures of executive function during the sub-acute phase of TBI.
AB - Background: Impairment in cognitive function is a recognized outcome of traumatic brain injury (TBI). However, the degree of impairment has variable relationship with TBI severity and time post injury. The underlying pathology is often due to diffuse axonal injury that has been found even in mild TBI. In this study, we examine the state of white matter putative connectivity in patients with non-severe TBI in the subacute phase, i.e., within 10 weeks of injury and determine its relationship with neuropsychological scores. Methods: We conducted a case-control prospective study involving 11 male adult patients with non-severe TBI and an age-matched control group of 11 adult male volunteers. Diffusion MRI scanning and neuropsychological tests were administered within 10 weeks post injury. The difference in fractional anisotropy (FA) values between the patient and control groups was examined using tract-based spatial statistics. The FA values that were significantly different between patients and controls were then correlated with neuropsychological tests in the patient group. Results: Several clusters with peak voxels of significant FA reductions (p < 0.05) in the white matter skeleton were seen in patients compared to the control group. These clusters were located in the superior fronto-occipital fasciculus, superior longitudinal fasciculus, uncinate fasciculus, and cingulum, as well as white matter fibers in the area of genu of corpus callosum, anterior corona radiata, superior corona radiata, anterior thalamic radiation and part of inferior frontal gyrus. Mean global FA magnitude correlated significantly with MAVLT immediate recall scores while matrix reasoning scores correlated positively with FA values in the area of right superior fronto-occipital fasciculus and left anterior corona radiata. Conclusion: The non-severe TBI patients had abnormally reduced FA values in multiple regions compared to controls that correlated with several measures of executive function during the sub-acute phase of TBI.
KW - diffusion MRI
KW - fractional anisotropy
KW - neuropsychological test
KW - tract-based spatial statistic
KW - traumatic brain injury
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U2 - 10.3389/fneur.2022.1011304
DO - 10.3389/fneur.2022.1011304
M3 - Article
AN - SCOPUS:85140375966
SN - 1664-2295
VL - 13
JO - Frontiers in Neurology
JF - Frontiers in Neurology
M1 - 1011304
ER -