Dissolving polyvinylpyrrolidone-based microneedle systems for in-vitro delivery of sumatriptan succinate

P. Ronnander, L. Simon, H. Spilgies, A. Koch, S. Scherr

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

In-vitro permeation studies were conducted to assess the feasibility of fabricating dissolving-microneedle-array systems to release sumatriptan succinate. The formulations consisted mainly of the encapsulated active ingredient and a water-soluble biologically compatible polymer, polyvinylpyrrolidone (PVP), approved by the U.S. Food and Drug Administration (FDA). Tests with Franz-type diffusion cells and Göttingen minipig skins showed an increase of the transdermal flux compared to passive diffusion. A preparation, containing 30% by mass of PVP and 8.7 mg sumatriptan, produced a delivery rate of 395 ± 31 μg/cm2 h over a 7-hour period after a negligible lag time of approximately 39 min. Theoretically, a 10.7 cm2 microneedle-array patch loaded with 118.8 mg of the drug would provide the required plasma concentration, 72 ng/mL, for nearly 7 h.

Original languageEnglish (US)
Pages (from-to)84-92
Number of pages9
JournalEuropean Journal of Pharmaceutical Sciences
Volume114
DOIs
StatePublished - Mar 1 2018

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

Keywords

  • Controlled release
  • Diffusion
  • Dissolving microneedles
  • Göttingen minipig
  • Polyvinylpyrrolidone
  • Sumatriptan succinate

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