Dye-sensitized core/active shell upconversion nanoparticles for optogenetics and bioimaging applications

Xiang Wu; Yuanwei Zhang; Kendra Takle; Osman Bilsel; Zhanjun Li; Hyungseok Lee; Zijiao Zhang; Dongsheng Li; Wei Fan; Chunying Duan; Emory M. Chan; Carlos Lois; Yang Xiang; Gang Han

doi:10.1021/acsnano.5b06383

Dye-sensitized core/active shell upconversion nanoparticles for optogenetics and bioimaging applications

Xiang Wu, Yuanwei Zhang, Kendra Takle, Osman Bilsel, Zhanjun Li, Hyungseok Lee, Zijiao Zhang, Dongsheng Li, Wei Fan, Chunying Duan, Emory M. Chan, Carlos Lois, Yang Xiang, Gang Han

Research output: Contribution to journal › Article › peer-review

400 Scopus citations

Abstract

Near-infrared (NIR) dye-sensitized upconversion nanoparticles (UCNPs) can broaden the absorption range and boost upconversion efficiency of UCNPs. Here, we achieved significantly enhanced upconversion luminescence in dye-sensitized core/active shell UCNPs via the doping of ytterbium ions (Yb³⁺) in the UCNP shell, which bridged the energy transfer from the dye to the UCNP core. As a result, we synergized the two most practical upconversion booster effectors (dye-sensitizing and core/shell enhancement) to amplify upconversion efficiency. We demonstrated two biomedical applications using these UCNPs. By using dye-sensitized core/active shell UCNP embedded poly(methyl methacrylate) polymer implantable systems, we successfully shifted the optogenetic neuron excitation window to a biocompatible and deep tissue penetrable 800 nm wavelength. Furthermore, UCNPs were water-solubilized with Pluronic F127 with high upconversion efficiency and can be imaged in a mouse model.

Original language	English (US)
Pages (from-to)	1060-1066
Number of pages	7
Journal	ACS Nano
Volume	10
Issue number	1
DOIs	https://doi.org/10.1021/acsnano.5b06383
State	Published - Jan 26 2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Materials Science
General Engineering
General Physics and Astronomy

Keywords

Bioimaging
Core/active shell structure
Dye-sensitizing
Near-infrared
Optogenetics
Upconversion nanoparticles

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10.1021/acsnano.5b06383

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title = "Dye-sensitized core/active shell upconversion nanoparticles for optogenetics and bioimaging applications",

abstract = "Near-infrared (NIR) dye-sensitized upconversion nanoparticles (UCNPs) can broaden the absorption range and boost upconversion efficiency of UCNPs. Here, we achieved significantly enhanced upconversion luminescence in dye-sensitized core/active shell UCNPs via the doping of ytterbium ions (Yb3+) in the UCNP shell, which bridged the energy transfer from the dye to the UCNP core. As a result, we synergized the two most practical upconversion booster effectors (dye-sensitizing and core/shell enhancement) to amplify upconversion efficiency. We demonstrated two biomedical applications using these UCNPs. By using dye-sensitized core/active shell UCNP embedded poly(methyl methacrylate) polymer implantable systems, we successfully shifted the optogenetic neuron excitation window to a biocompatible and deep tissue penetrable 800 nm wavelength. Furthermore, UCNPs were water-solubilized with Pluronic F127 with high upconversion efficiency and can be imaged in a mouse model.",

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author = "Xiang Wu and Yuanwei Zhang and Kendra Takle and Osman Bilsel and Zhanjun Li and Hyungseok Lee and Zijiao Zhang and Dongsheng Li and Wei Fan and Chunying Duan and Chan, {Emory M.} and Carlos Lois and Yang Xiang and Gang Han",

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doi = "10.1021/acsnano.5b06383",

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T1 - Dye-sensitized core/active shell upconversion nanoparticles for optogenetics and bioimaging applications

AU - Wu, Xiang

AU - Zhang, Yuanwei

AU - Takle, Kendra

AU - Bilsel, Osman

AU - Li, Zhanjun

AU - Lee, Hyungseok

AU - Zhang, Zijiao

AU - Li, Dongsheng

AU - Fan, Wei

AU - Duan, Chunying

AU - Chan, Emory M.

AU - Lois, Carlos

AU - Xiang, Yang

AU - Han, Gang

PY - 2016/1/26

Y1 - 2016/1/26

N2 - Near-infrared (NIR) dye-sensitized upconversion nanoparticles (UCNPs) can broaden the absorption range and boost upconversion efficiency of UCNPs. Here, we achieved significantly enhanced upconversion luminescence in dye-sensitized core/active shell UCNPs via the doping of ytterbium ions (Yb3+) in the UCNP shell, which bridged the energy transfer from the dye to the UCNP core. As a result, we synergized the two most practical upconversion booster effectors (dye-sensitizing and core/shell enhancement) to amplify upconversion efficiency. We demonstrated two biomedical applications using these UCNPs. By using dye-sensitized core/active shell UCNP embedded poly(methyl methacrylate) polymer implantable systems, we successfully shifted the optogenetic neuron excitation window to a biocompatible and deep tissue penetrable 800 nm wavelength. Furthermore, UCNPs were water-solubilized with Pluronic F127 with high upconversion efficiency and can be imaged in a mouse model.

AB - Near-infrared (NIR) dye-sensitized upconversion nanoparticles (UCNPs) can broaden the absorption range and boost upconversion efficiency of UCNPs. Here, we achieved significantly enhanced upconversion luminescence in dye-sensitized core/active shell UCNPs via the doping of ytterbium ions (Yb3+) in the UCNP shell, which bridged the energy transfer from the dye to the UCNP core. As a result, we synergized the two most practical upconversion booster effectors (dye-sensitizing and core/shell enhancement) to amplify upconversion efficiency. We demonstrated two biomedical applications using these UCNPs. By using dye-sensitized core/active shell UCNP embedded poly(methyl methacrylate) polymer implantable systems, we successfully shifted the optogenetic neuron excitation window to a biocompatible and deep tissue penetrable 800 nm wavelength. Furthermore, UCNPs were water-solubilized with Pluronic F127 with high upconversion efficiency and can be imaged in a mouse model.

KW - Bioimaging

KW - Core/active shell structure

KW - Dye-sensitizing

KW - Near-infrared

KW - Optogenetics

KW - Upconversion nanoparticles

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Dye-sensitized core/active shell upconversion nanoparticles for optogenetics and bioimaging applications

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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