@inproceedings{4cb849488ebf4fbfb2e879917be3ff7f,
title = "Dynamic analysis and performance evaluation of the BIAcore surface plasmon resonance biosensor",
abstract = "Solution procedures were proposed to analyze nonlinear mass transport through an optical biosensor. A generalized collocation technique was applied to predict the dynamic behavior of an analyte along the flow chamber as a result of convection, diffusion and chemical reaction. The method estimated the effective time constants for reaching average steady-state concentrations of the free and bound analytes in the cell. When diffusion in the direction of flow was neglected, a closed-form solution, based on double Laplace transforms, was obtained after linearizing the original system. In both models, an increase in the sample diffusion coefficient lowered the effective time constant. This approach may help researchers evaluate the performance of biosensors and meet specific design criteria.",
keywords = "Collocation, Double Laplace transform, Effective time constant, Optical biosensor",
author = "Laurent Simon and Juan Ospina",
note = "Publisher Copyright: {\textcopyright} 2015 SPIE.; Smart Biomedical and Physiological Sensor Technology XII ; Conference date: 23-04-2015 Through 24-04-2015",
year = "2015",
doi = "10.1117/12.2177807",
language = "English (US)",
series = "Proceedings of SPIE - The International Society for Optical Engineering",
publisher = "SPIE",
editor = "Cullum, {Brian M.} and McLamore, {Eric S.}",
booktitle = "Smart Biomedical and Physiological Sensor Technology XII",
address = "United States",
}