Dynamic analysis and performance evaluation of the BIAcore surface plasmon resonance biosensor

Laurent Simon, Juan Ospina

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Solution procedures were proposed to analyze nonlinear mass transport through an optical biosensor. A generalized collocation technique was applied to predict the dynamic behavior of an analyte along the flow chamber as a result of convection, diffusion and chemical reaction. The method estimated the effective time constants for reaching average steady-state concentrations of the free and bound analytes in the cell. When diffusion in the direction of flow was neglected, a closed-form solution, based on double Laplace transforms, was obtained after linearizing the original system. In both models, an increase in the sample diffusion coefficient lowered the effective time constant. This approach may help researchers evaluate the performance of biosensors and meet specific design criteria.

Original languageEnglish (US)
Title of host publicationSmart Biomedical and Physiological Sensor Technology XII
EditorsBrian M. Cullum, Eric S. McLamore
PublisherSPIE
ISBN (Electronic)9781628416039
DOIs
StatePublished - Jan 1 2015
EventSmart Biomedical and Physiological Sensor Technology XII - Baltimore, United States
Duration: Apr 23 2015Apr 24 2015

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume9487
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Other

OtherSmart Biomedical and Physiological Sensor Technology XII
CountryUnited States
CityBaltimore
Period4/23/154/24/15

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Keywords

  • Collocation
  • Double Laplace transform
  • Effective time constant
  • Optical biosensor

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