Dynamic Configuration of Coactive Micropatterns in the Default Mode Network during Wakefulness and Sleep

Yan Cui, Min Li, Bharat Biswal, Wei Jing, Changsong Zhou, Huixiao Liu, Daqing Guo, Yang Xia, Dezhong Yao

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The default mode network (DMN) is a prominent intrinsic network that is observable in many mammalian brains. However, a few studies have investigated the temporal dynamics of this network based on direct physiological recordings. Methods: Herein, we addressed this issue by characterizing the dynamics of local field potentials from the rat DMN during wakefulness and sleep with an exploratory analysis. We constructed a novel coactive micropattern (CAMP) algorithm to evaluate the configurations of rat DMN dynamics, and further revealed the relationship between DMN dynamics with different wakefulness and alertness levels. Results: From the gamma activity (40-80 Hz) in the DMN across wakefulness and sleep, three spatially stable CAMPs were detected: a common low-activity level micropattern (cDMN), an anterior high-activity level micropattern (aDMN), and a posterior high-activity level micropattern (pDMN). A dynamic balance across CAMPs emerged during wakefulness and was disrupted in sleep stages. In the slow-wave sleep (SWS) stage, cDMN became the primary activity pattern, whereas aDMN and pDMN were the major activity patterns in the rapid eye movement sleep stage. In addition, further investigation revealed phasic relationships between CAMPs and the up-down states of the slow DMN activity in the SWS stage. Conclusion: Our study revealed that the dynamic configurations of CAMPs were highly associated with different stages of wakefulness, and provided a potential three-state model to describe the DMN dynamics for wakefulness and alertness. In the current study, a novel coactive micropattern (CAMP) method was developed to elucidate fast default mode network (DMN) dynamics during wakefulness and sleep. Our findings demonstrated that the dynamic configurations of DMN activity are specific to different wakefulness stages and provided a three-state DMN CAMP model to depict wakefulness levels, thus revealing a potentially new neurophysiological representation of alertness levels. This work could elucidate the DMN dynamics underlying different stages of wakefulness and have important implications for the theoretical understanding of the neural mechanism of wakefulness and alertness.

Original languageEnglish (US)
Pages (from-to)471-482
Number of pages12
JournalBrain connectivity
Volume11
Issue number6
DOIs
StatePublished - Aug 2021

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Keywords

  • coactive micropattern
  • default mode network
  • dynamic configuration
  • up-down states
  • wakefulness and sleep

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