Effect of anesthesia on CBF, MAP and fMRI-BOLD signal in response to apnea

Sridhar S. Kannurpatti, Bharat B. Biswal

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Systemic effects of anesthesia on the dynamics of the apnea-induced Blood Oxygen Level Dependent (BOLD) signal is still not clear. In the present study, the dynamics of the fMRI-BOLD signal and blood flow using laser Doppler flowmetry (LDF) was studied in rats in response to apnea. Two anesthetics namely pentobarbital and urethane, hypothesized to have distinct effects on the mean arterial blood pressure (MAP) were used. During normoxic baseline conditions, MAP decreased in response to apnea in rats anesthetized with pentobarbital but increased with urethane. However, MAP did not change significantly in response to apnea during hyperoxic or hypercapnic baseline conditions with both anesthetics. LDF increased in response to apnea during normoxia, hyperoxia or hypercapnia and was influenced by MAP during normoxia. Apnea-induced BOLD signal dynamics was similar with both anesthetics, dominated by an alteration in arterial blood oxygenation and independent of changes in MAP. Our results suggest that anesthesia-dependent MAP change modulates the apnea-induced cerebral blood flow (CBF) response but has a minimal effect on the fMRI-BOLD signal probably due to uncoupling of CBF and oxygen consumption.

Original languageEnglish (US)
Pages (from-to)141-147
Number of pages7
JournalBrain Research
Volume1011
Issue number2
DOIs
StatePublished - Jun 18 2004
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Keywords

  • Anesthesia
  • Apnea
  • Functional magnetic resonance imaging
  • Hypoxia
  • LDF
  • Laser Doppler flowmetry
  • MAP
  • Mean arterial pressure
  • fMRI
  • functional magnetic resonance imaging
  • laser Doppler flowmetry
  • mean arterial pressure

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