TY - GEN
T1 - Effect of gold nanoparticle size on their properties as contrast agents for computed tomography
AU - Dong, Yuxi
AU - Hajfathalian, Maryam
AU - Hsu, Jessica
AU - Naha, Pratap C.
AU - Kim, Johoon
AU - Chhour, Peter
AU - Maidment, Portia
AU - Litt, Harold I.
AU - Cormode, David P.
N1 - Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: Gold nanoparticles (AuNP) are of considerable interest as CT contrast agents. AuNP have favorable characteristics for this application such as strong X-ray attenuation, excellent biocompatibility, and tunable sizes and shapes. However, there have been conflicting reports on the role of gold nanoparticle size on their performance as contrast agents for CT, despite the fact that physics indicates that there should be no effect of AuNP size. Therefore, we herein sought to test the hypothesis that AuNP size would not affect AuNP CT contrast properties. On the other hand, pharmacokinetics and biodistribution may vary significantly as AuNP size changes, and will impact their potential utility as CT imaging contrast agents. We therefore sought to understand the role of size on pharmacokinetics and biodistribution via in vivo studies of AuNP ranging in size from 4 to 79 nm.
AB - Statement of Purpose: Gold nanoparticles (AuNP) are of considerable interest as CT contrast agents. AuNP have favorable characteristics for this application such as strong X-ray attenuation, excellent biocompatibility, and tunable sizes and shapes. However, there have been conflicting reports on the role of gold nanoparticle size on their performance as contrast agents for CT, despite the fact that physics indicates that there should be no effect of AuNP size. Therefore, we herein sought to test the hypothesis that AuNP size would not affect AuNP CT contrast properties. On the other hand, pharmacokinetics and biodistribution may vary significantly as AuNP size changes, and will impact their potential utility as CT imaging contrast agents. We therefore sought to understand the role of size on pharmacokinetics and biodistribution via in vivo studies of AuNP ranging in size from 4 to 79 nm.
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M3 - Conference contribution
AN - SCOPUS:85065451148
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 821
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -