Effect of heart rate on the canine end-systolic pressure-volume relationship

W. L. Maughan, K. Sunagawa, D. Burkhoff, W. L. Graves, W. C. Hunter, K. Sagawa

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89 Scopus citations


Although the rate dependence of isolated muscle contractility is well known, the ventricular end-systolic pressure-volume relationship (ESPVR) has been reported to be insensitive to heart rate. To resolve this contradiction, we used an isolated, ejecting canine heart preparation perfused at a constant coronary arterial pressure. Heart rate was changed from 60 to 200 beats/min in steps of 20 beats/min. At least 10 pressure-volume loops under different filling pressures were obtained at each heart rate in each of six hearts. Over a heart rate range from 60 to 120 beats/min, the slope of the ESPVR (E(es)) increased significantly from 3.5 ± 0.4 (SE) to 5.3 ± 0.6 mm Hg/ml. In the range between 120 and 180 beats/min there was little change in E(es) (5.3 ± 0.6 to 5.4 ± 0.6 mm Hg/ml), but at 200 beats/min E(es) increased slightly to 5.7 ± 0.5 mm Hg/ml. The volume axis intercept (V0) of the ESPVR changed little over the range of heart rate from 60 to 160 beats/min (10.2 ± 2 ml to 9.4 ± 1.3 ml) but increased to 15.2 ± 1.2 ml at a rate of 200 beats/min. The change in ESPVR with increase in heart rate from 60 to 120 beats/min (i.e., increase in E(es) without change in V(0) is the same as those seen with a positive intropic intervention with calcium or cathecholamines, whereas the V0 changes over the range from 160 to 200 beats/min is similar to those seen with regional ischemia. The insensitivity of ESPVR in the midrange may be the result of a balance of positive and negative influences on ventricular contraction or a restricted range for the increase in inotropic state with higher rate.

Original languageEnglish (US)
Pages (from-to)654-659
Number of pages6
Issue number3
StatePublished - 1985
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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