Effect of nitroglycerin on aortic impedance, diameter, and pulse-wave velocity

T. W. Latson, W. C. Hunter, N. Katoh, K. Sagawa

Research output: Contribution to journalArticlepeer-review

93 Scopus citations


The effects of an intravenous infusion of 1 μg/kg nitroglycerin were studied on systemic arterial properties in nine acutely instrumented dogs. Aortic impedance and pulse-wave velocity were calculated from measured pressure and flow signals collected during random ventricular pacing. Central aortic diameter was simultaneously determined with ultrasonic dimension crystals. Mean blood pressure was maintained constant to avoid the confounding effects of passive, pressure-induced changes in vascular properties. Nitroglycerin both reduced the amplitude of peripheral vascular reflections and delayed the return of these reflections to the aortic root. This reflection delay was manifested as a consistent leftward shift in both impedance modulus and phase. The magnitude of this reflection delay could not be entirely accounted for on the basis of the measured changes in average pulse-wave velocity along the aorta.

Original languageEnglish (US)
Pages (from-to)884-890
Number of pages7
JournalCirculation Research
Issue number5
StatePublished - 1988
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine


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