Effect of solvents on stabilization of micro drug particles

Chintal Desai; Xiangxin Meng; Dachuan Yang; Xianqin Wang; Vamshi Akkunuru; Somenath Mitra

doi:10.1016/j.jcrysgro.2010.11.153

Effect of solvents on stabilization of micro drug particles

Chintal Desai, Xiangxin Meng, Dachuan Yang, Xianqin Wang, Vamshi Akkunuru, Somenath Mitra

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Antisolvent synthesis of micron scale Griseofulvin was carried out with simultaneous suspension stabilization under low power ultrasonic agitation. The organic solvent plays an important role because the supersaturation could be varied by using different solvents and the physicochemical characteristics of the suspension are also altered, which affects stability. In this study we present the effect of solvents on particle formation, polymorphism and stability of micron scale Griseofulvin formation in aqueous media.

Original language	English (US)
Pages (from-to)	353-358
Number of pages	6
Journal	Journal of Crystal Growth
Volume	314
Issue number	1
DOIs	https://doi.org/10.1016/j.jcrysgro.2010.11.153
State	Published - Jan 1 2011

All Science Journal Classification (ASJC) codes

Condensed Matter Physics
Inorganic Chemistry
Materials Chemistry

Keywords

A1. Solvents
A1. Stability
A2. Antisolvent
A2. Drug particles
B1. Colloid

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10.1016/j.jcrysgro.2010.11.153

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AU - Desai, Chintal

AU - Meng, Xiangxin

AU - Yang, Dachuan

AU - Wang, Xianqin

AU - Akkunuru, Vamshi

AU - Mitra, Somenath

PY - 2011/1/1

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AB - Antisolvent synthesis of micron scale Griseofulvin was carried out with simultaneous suspension stabilization under low power ultrasonic agitation. The organic solvent plays an important role because the supersaturation could be varied by using different solvents and the physicochemical characteristics of the suspension are also altered, which affects stability. In this study we present the effect of solvents on particle formation, polymorphism and stability of micron scale Griseofulvin formation in aqueous media.

KW - A1. Solvents

KW - A1. Stability

KW - A2. Antisolvent

KW - A2. Drug particles

KW - B1. Colloid

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EP - 358

JO - Journal of Crystal Growth

JF - Journal of Crystal Growth

IS - 1

ER -

Effect of solvents on stabilization of micro drug particles

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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