Effect of solvents on stabilization of micro drug particles

Chintal Desai, Xiangxin Meng, Dachuan Yang, Xianqin Wang, Vamshi Akkunuru, Somenath Mitra

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Antisolvent synthesis of micron scale Griseofulvin was carried out with simultaneous suspension stabilization under low power ultrasonic agitation. The organic solvent plays an important role because the supersaturation could be varied by using different solvents and the physicochemical characteristics of the suspension are also altered, which affects stability. In this study we present the effect of solvents on particle formation, polymorphism and stability of micron scale Griseofulvin formation in aqueous media.

Original languageEnglish (US)
Pages (from-to)353-358
Number of pages6
JournalJournal of Crystal Growth
Volume314
Issue number1
DOIs
StatePublished - Jan 1 2011

All Science Journal Classification (ASJC) codes

  • Condensed Matter Physics
  • Inorganic Chemistry
  • Materials Chemistry

Keywords

  • A1. Solvents
  • A1. Stability
  • A2. Antisolvent
  • A2. Drug particles
  • B1. Colloid

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